Gene: CNOT2
Official Full Name: CCR4-NOT transcription complex subunit 2provided by HGNC
Gene Summary: This gene encodes a subunit of the multi-component CCR4-NOT complex. The CCR4-NOT complex regulates mRNA synthesis and degradation and is also thought to be involved in mRNA splicing, transport and localization. The encoded protein interacts with histone deacetylases and functions as a repressor of polymerase II transcription. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO00925 | CNOT2 Knockout cell line(HeLa) | Human | CNOT2 | 1:3~1:6 | Negative | Online Inquiry |
CNOT2 Gene Knockout Cell Lines are meticulously developed cell models designed to facilitate the study of the CNOT2 gene's functions and regulatory mechanisms within cellular processes. The CNOT2 gene encodes a protein that is a crucial component of the CCR4-NOT complex, which influences mRNA stability, transcriptional regulation, and cellular responses to environmental stimuli. By utilizing CRISPR/Cas9 technology, these knockout cell lines effectively eliminate the expression of the CNOT2 gene, allowing researchers to investigate the impacts of its absence on gene expression, cell proliferation, differentiation, and response to stressors.
The key function of CNOT2 lies in its role as a regulator of RNA metabolism, influencing both mRNA degradation and translation efficiency. In research settings, these knockout cell lines serve as pivotal tools for elucidating the molecular pathways and cellular mechanisms governed by CNOT2, which are relevant in various biological contexts, including cancer biology, immunology, and neurobiology. Clinically, insights gained from studies utilizing CNOT2 knockout models may contribute to the understanding of disease mechanisms and the development of targeted therapies.
The specific advantages of CNOT2 Gene Knockout Cell Lines compared to alternative models include their precise genetic alteration, a wide variety of available cell types, and the ability to produce consistent and reproducible results. These features make them invaluable for researchers who require high-fidelity models for functional assays and drug screening.
For researchers and clinicians seeking to advance their understanding of gene function and regulation, CNOT2 Gene Knockout Cell Lines offer a streamlined and effective approach to unlocking new discoveries. Our company prides itself on delivering high-quality biological products, supported by a team of experts dedicated to providing comprehensive resources for innovative research.
Please note that all services are for research use only. Not intended for any clinical use.
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