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CLIC3 Knockout Cell Lines

Gene: CLIC3

Official Full Name: chloride intracellular channel 3provided by HGNC

Gene Summary: Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 3 is a member of the p64 family and is predominantly localized in the nucleus and stimulates chloride ion channel activity. In addition, this protein may participate in cellular growth control, based on its association with ERK7, a member of the MAP kinase family. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO33648 CLIC3 Knockout cell line (HeLa) Human CLIC3 1:3~1:6 Negative Online Inquiry
KO33649 CLIC3 Knockout cell line (HCT 116) Human CLIC3 1:2~1:4 Negative Online Inquiry
KO33650 CLIC3 Knockout cell line (A549) Human CLIC3 1:3~1:4 Negative Online Inquiry

Background

CLIC3 Gene Knockout Cell Lines are specialized cellular models designed to study the functional role of the CLIC3 gene in various biological processes. CLIC3, or Chloride Intracellular Channel 3, is integral to cellular homeostasis and ion transport mechanisms. By employing CRISPR-Cas9 gene editing technology, these knockout cell lines effectively eliminate CLIC3 expression, allowing researchers to dissect its impact on cellular signaling, membrane dynamics, and associated pathophysiological conditions.

The key function of CLIC3 Gene Knockout Cell Lines lies in their ability to serve as a powerful tool in the investigation of chloride ion transport and its implications in processes such as cell proliferation, apoptosis, and inflammation. By comparing these knockout lines to their wild-type counterparts, researchers can uncover the underlying mechanisms through which CLIC3 influences these critical cellular pathways, providing insights into potential therapeutic targets for diseases where chloride transport dysfunction is implicated, such as cystic fibrosis and certain cancers.

The scientific importance of the CLIC3 Gene Knockout Cell Lines extends to both basic and applied research. In clinical settings, they can aid in drug discovery by identifying novel targets for pharmacological intervention. For example, understanding the role of CLIC3 in ion transport may lead to innovative treatments that manipulate this pathway.

In comparison to conventional knockout models, our CLIC3 Gene Knockout Cell Lines offer superior precision and reliability due to the advanced CRISPR-Cas9 approach, which results in more consistent genetic modifications. Furthermore, they are readily available and easy to work with, streamlining the research process and enhancing reproducibility across experiments.

Researchers and clinicians will find immense value in the CLIC3 Gene Knockout Cell Lines as they present a unique opportunity to explore the complexities of chloride signaling in diverse biological contexts. With our commitment to excellence in biological products and our state-of-the-art gene editing capabilities, we are dedicated to supporting the scientific community by providing advanced tools that drive innovation and discovery.

Please note that all services are for research use only. Not intended for any clinical use.

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