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CLDN7 Knockout Cell Lines

Gene: CLDN7

Official Full Name: claudin 7provided by HGNC

Gene Summary: This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Differential expression of this gene has been observed in different types of malignancies, including breast cancer, ovarian cancer, hepatocellular carcinomas, urinary tumors, prostate cancer, lung cancer, head and neck cancers, thyroid carcinomas, etc.. Alternatively spliced transcript variants encoding different isoforms have been found.[provided by RefSeq, May 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO38445 CLDN7 Knockout cell line (HeLa) Human CLDN7 1:3~1:6 Negative Online Inquiry
KO38446 CLDN7 Knockout cell line (HCT 116) Human CLDN7 1:2~1:4 Negative Online Inquiry
KO38447 CLDN7 Knockout cell line (HEK293) Human CLDN7 1:3~1:6 Negative Online Inquiry
KO38448 CLDN7 Knockout cell line (A549) Human CLDN7 1:3~1:4 Negative Online Inquiry

Background

CLDN7 Gene Knockout Cell Lines are specialized biological tools developed to facilitate the exploration of the CLDN7 gene's function in cell signaling, adhesion, and tissue homeostasis. These cell lines have been engineered to lack the CLDN7 gene, providing a model system to study the consequences of its absence on cellular processes and interactions. By offering insights into the roles of claudin proteins in tight junction formation and integrity, these knockout cell lines enable researchers to dissect the underlying mechanisms that contribute to various pathologies, including cancer and inflammatory diseases.

The primary function of these CLDN7 knockout cell lines is to support investigations into how the loss of CLDN7 affects cellular behavior, such as proliferation, migration, and apoptosis. Utilizing established techniques like CRISPR-Cas9 gene editing, these cell lines exhibit a high specificity in gene disruption, ensuring that the results obtained are directly attributable to the absence of CLDN7. This powerful approach enhances the reliability of experimental outcomes and allows for the exploration of compensatory pathways that may otherwise obscure the effects of gene knockouts.

Scientifically, the CLDN7 Gene Knockout Cell Lines hold significant importance in both research and clinical applications. They serve as indispensable models for studying tight junction dynamics and their implications in disease states. Researchers in fields such as oncology and gastroenterology can utilize these models to identify potential therapeutic targets and to evaluate the efficacy of drug candidates aimed at modulating tight junction behavior.

One of the primary advantages of our CLDN7 knockout cell lines is their superior quality and reliability, compared to alternative models that may rely on RNA interference or less precise gene-editing methods. Our cell lines are validated for consistent performance in various assays, ensuring reproducible results across experiments. Additionally, they come with comprehensive technical support, enabling users to maximize the potential of this resource.

Valuable to researchers and clinicians alike, these knockout cell lines represent a critical advancement in the study of cellular mechanisms that underlie numerous diseases. By leveraging this state-of-the-art product, stakeholders can enhance their research outcomes and drive innovations in therapeutic development. Our company, backed by extensive expertise in biotechnological applications and a commitment to quality, delivers pioneering biological products that empower scientific discovery and progress.

Please note that all services are for research use only. Not intended for any clinical use.

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