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CLCN6 Knockout Cell Lines

Gene: CLCN6

Official Full Name: chloride voltage-gated channel 6provided by HGNC

Gene Summary: This gene encodes a member of the voltage-dependent chloride channel protein family. Members of this family can function as either chloride channels or antiporters. This protein is primarily localized to late endosomes and functions as a chloride/proton antiporter. Alternate splicing results in both coding and non-coding variants. Additional alternately spliced variants have been described but their full-length structure is unknown. [provided by RefSeq, Mar 2012]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO00361 CLCN6 Knockout cell line (HeLa) Human CLCN6 1:3~1:6 Negative Online Inquiry
KO05486 CLCN6 Knockout cell line (HCT 116) Human CLCN6 1:2~1:4 Negative Online Inquiry
KO05487 CLCN6 Knockout cell line (HEK293) Human CLCN6 1:3~1:6 Negative Online Inquiry
KO05488 CLCN6 Knockout cell line (A549) Human CLCN6 1:3~1:4 Negative Online Inquiry

Background

CLCN6 Gene Knockout Cell Lines are meticulously engineered cellular models designed to facilitate the in-depth study of CLCN6 gene function, associated pathways, and their implications in physiological and pathological conditions. The CLCN6 gene encodes a member of the chloride channel family, which plays a crucial role in maintaining cellular ion balance and volume regulation. By creating knockout variants, researchers can effectively observe the cellular responses and underlying mechanisms when the expression of this gene is eliminated, providing insights into its specific contributions to various biological processes.

The primary function of these cell lines is to serve as powerful tools in elucidating the role of CLCN6 in cellular physiology. By studying CLCN6 knockout cells, scientists can assess alterations in ion homeostasis, membrane potential, and the resultant physiological effects, effectively allowing for the modeling of diseases linked to chloride channel dysfunction. This is particularly relevant in neurophysiology and developmental biology, where the dysregulation of ion channels is implicated in numerous disorders.

The scientific importance of CLCN6 Gene Knockout Cell Lines extends into both basic and applied research, enabling investigations into genetic disorders, drug responses, and potential therapeutic targets. Their use is pivotal in preclinical studies for drug discovery and development, contributing to the understanding of how CLCN6-related pathways might be modulated for therapeutic benefit.

Compared to traditional methods such as chemical inhibitors or RNA interference, CLCN6 Gene Knockout Cell Lines offer a permanent and stable alteration in gene expression, thereby providing more consistent and reproducible results. This permanence allows researchers to conduct long-term studies, observing phenotypic changes over time without the variability introduced by transient knockdown strategies, making them invaluable for rigorous scientific investigations.

For researchers and clinicians, the significant information obtained from these knockout models translates into actionable knowledge, aiding in the development of targeted biomedical therapies and enhancing the understanding of disease mechanisms. The availability of reliable and validated CLCN6 Gene Knockout Cell Lines from our company, a leader in producing high-quality biological products, signifies our commitment to advancing research and clinical outcomes through innovative solutions in cellular biology. With a focus on precision and reliability, our offerings empower the scientific community to push the boundaries of knowledge and therapeutic approaches.

Please note that all services are for research use only. Not intended for any clinical use.

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