Gene: CKMT2
Official Full Name: creatine kinase, mitochondrial 2provided by HGNC
Gene Summary: Mitochondrial creatine kinase (MtCK) is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Sarcomeric mitochondrial creatine kinase has 80% homology with the coding exons of ubiquitous mitochondrial creatine kinase. This gene contains sequences homologous to several motifs that are shared among some nuclear genes encoding mitochondrial proteins and thus may be essential for the coordinated activation of these genes during mitochondrial biogenesis. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO38538 | CKMT2 Knockout cell line (HEK293) | Human | CKMT2 | 1:3~1:6 | Negative | Online Inquiry |
CKMT2 Gene Knockout Cell Lines are advanced biological tools specifically engineered for the study of the CKMT2 gene, which encodes the mitochondrial creatine kinase. This enzyme is crucial for facilitating energy transfer within the mitochondria by catalyzing the conversion of creatine and ATP to phosphocreatine and ADP, thereby playing a pivotal role in cellular energy metabolism. By knocking out the CKMT2 gene, these cell lines allow researchers to investigate the gene's function and its implications in various physiological and pathological contexts.
The primary function of CKMT2 Gene Knockout Cell Lines lies in their ability to elucidate the consequences of CKMT2 deletion on mitochondrial function and cellular energy homeostasis. Researchers can observe changes in metabolic profiles, ATP production, and responses to cellular stress, providing insights into the role of CKMT2 in metabolic disorders, muscle function, and neurodegenerative diseases. This mechanistic understanding is critical for exploring potential therapeutic targets and interventions.
From a scientific perspective, these cell lines are invaluable in translational research, particularly in studies focused on metabolic diseases, cancer, and mitochondrial dysfunction. They provide a controlled environment for examining the effects of genetic deletion with respect to various treatments, genetic modifications, and environmental conditions. Compared to conventional cell lines, the CKMT2 knockout variants eliminate confounding effects related to the expression of CKMT2, allowing for more precise experimental outcomes.
One of the key advantages of CKMT2 Gene Knockout Cell Lines is their specificity, as they enable researchers to target the exact pathways influenced by CKMT2 without interference from other genes. Additionally, these lines are validated for consistent performance across experiments, reducing variability that can complicate data interpretation. Moreover, they are an excellent complement to CRISPR technology, enabling deeper insights into gene-gene interactions and cellular pathways in a reproducible manner.
For researchers and clinicians, investing in CKMT2 Gene Knockout Cell Lines means accessing high-quality, reliable tools tailored for groundbreaking studies in mitochondrial biology and energy metabolism. As a company specializing in cellular and molecular biology products, we pride ourselves on delivering innovative solutions backed by rigorous scientific validation, empowering your research to achieve transformative results in understanding human health and disease.
Please note that all services are for research use only. Not intended for any clinical use.
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