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CISD3 Knockout Cell Lines

Gene: CISD3

Official Full Name: CDGSH iron sulfur domain 3provided by HGNC

Gene Summary: CISD3 is a member of the CDGSH domain-containing family, which may play a role in regulating electron transport and oxidative phosphorylation (Wiley et al., 2007 [PubMed 17376863]).[supplied by OMIM, Apr 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO18686 CISD3 Knockout cell line (HeLa) Human CISD3 1:3~1:6 Negative Online Inquiry
KO18687 CISD3 Knockout cell line (HCT 116) Human CISD3 1:2~1:4 Negative Online Inquiry
KO18688 CISD3 Knockout cell line (A549) Human CISD3 1:3~1:4 Negative Online Inquiry

Background

CISD3 Gene Knockout Cell Lines represent a specialized tool for researchers investigating the multifaceted roles of the CISD3 gene, which encodes a protein implicated in cellular homeostasis and iron metabolism. These cell lines are generated using advanced CRISPR-Cas9 gene-editing technology, creating a model wherein the CISD3 gene is precisely disrupted. This knockout model allows scientists to explore the biological functions of CISD3 in pathophysiological contexts, particularly its relation to neurodegenerative diseases and cancer.

The primary function of CISD3 appears to be linked to mitochondrial dynamics, acting to regulate iron levels and oxidative stress within cells. By employing the CISD3 Gene Knockout Cell Lines, researchers can elucidate the downstream effects of CISD3 deficiency, including alterations in mitochondrial function and changes in cellular signaling pathways. These lines serve as a valuable platform for investigating potential therapeutic targets, as well as identifying biomarkers associated with diseases where CISD3 plays a critical role.

In terms of scientific importance, these knockout cell lines have significant applications in both fundamental research and clinical settings. They provide insights into disease mechanisms and therapeutic strategies, as researchers seek to identify how modulation of CISD3 expression could influence treatment outcomes. Compared to traditional cell models, these knockout lines offer enhanced specificity and reliability for studying gene function, making them indispensable for accurate experimental designs.

The unique selling points of the CISD3 Gene Knockout Cell Lines include their high fidelity in gene editing, reproducibility, and the comprehensive data generated from studies utilizing these models. This specificity not only streamlines research workflows but also enhances the overall data integrity, thereby fostering novel discoveries in mitochondrial biology and disease intervention.

In conclusion, the CISD3 Gene Knockout Cell Lines represent an invaluable asset for researchers and clinicians aiming to deepen their understanding of CISD3-related pathways. Our company prides itself on delivering high-quality, validated biological products, supported by expert insight and a commitment to advancing scientific research.

Please note that all services are for research use only. Not intended for any clinical use.

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