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CIR1 Knockout Cell Lines

Gene: CIR1

Official Full Name: corepressor of RBPJ and splicing regulatorprovided by HGNC

Gene Summary: Enables histone deacetylase binding activity; protein kinase binding activity; and transcription corepressor activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in centrosome and nuclear speck. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO11432 CIR1 Knockout cell line (HeLa) Human CIR1 1:3~1:6 Negative Online Inquiry
KO11433 CIR1 Knockout cell line (HCT 116) Human CIR1 1:2~1:4 Negative Online Inquiry
KO11434 CIR1 Knockout cell line (HEK293) Human CIR1 1:3~1:6 Negative Online Inquiry
KO11435 CIR1 Knockout cell line (A549) Human CIR1 1:3~1:4 Negative Online Inquiry

Background

CIR1 Gene Knockout Cell Lines are innovative cellular models engineered to facilitate the exploration of gene function and regulation by providing a platform where the CIR1 gene, known for its role in cellular signaling and metabolic processes, has been selectively disrupted. This genetic modification is achieved through precise genome-editing techniques, ensuring the complete depletion of CIR1 expression, which allows researchers to study the downstream effects of its absence in a controlled environment.

The key functionality of CIR1 Gene Knockout Cell Lines lies in their ability to simulate disease states by mimicking the genetic conditions that affect cellular behavior and physiology. By removing the CIR1 gene, these cell lines enable scientists to investigate various biological processes such as cellular proliferation, differentiation, and stress responses. Additionally, they serve as an essential tool for drug discovery and toxicity assessments, where understanding the impact of specific gene deletions on therapeutic outcomes is critical.

The scientific importance of these knockout cell lines cannot be overstated, as they play a vital role in both basic and applied research. In clinical settings, they are utilized to inform the understanding of diseases linked to CIR1 dysfunction, including metabolic disorders and certain cancers, ultimately guiding the development of targeted therapies.

In comparison with conventional cell lines, CIR1 Gene Knockout Cell Lines offer unique advantages, including higher specificity in modeling conditions related to CIR1 deficiency and enhanced reproducibility of experimental outcomes. The precision of gene editing in producing these knockout models surpasses that of traditional perturbation methods, making them superior tools for hypothesis testing.

For researchers and clinicians, the value of CIR1 Gene Knockout Cell Lines lies in their ability to provide critical insights into gene function, contribute to the understanding of disease mechanisms, and aid in the identification of potential therapeutic targets. Furthermore, our company prides itself on its extensive expertise in developing high-quality biological research tools, ensuring that each cell line meets rigorous standards for efficacy and reliability. By choosing our CIR1 Gene Knockout Cell Lines, users can be confident in their research's quality and relevance to advancing scientific knowledge in gene regulation and its implications in health and disease.

Please note that all services are for research use only. Not intended for any clinical use.

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