Gene: CILK1
Official Full Name: ciliogenesis associated kinase 1provided by HGNC
Gene Summary: Eukaryotic protein kinases are enzymes that belong to a very extensive family of proteins which share a conserved catalytic core common with both serine/threonine and tyrosine protein kinases. This gene encodes an intestinal serine/threonine kinase harboring a dual phosphorylation site found in mitogen-activating protein (MAP) kinases. The protein localizes to the intestinal crypt region and is thought to be important in intestinal epithelial cell proliferation and differentiation. Alternative splicing has been observed at this locus and two variants, encoding the same isoform, have been identified. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO04901 | CILK1 Knockout cell line (HeLa) | Human | CILK1 | 1:3~1:6 | Negative | Online Inquiry |
KO04902 | CILK1 Knockout cell line (HCT 116) | Human | CILK1 | 1:2~1:4 | Negative | Online Inquiry |
KO04903 | CILK1 Knockout cell line (HEK293) | Human | CILK1 | 1:3~1:6 | Negative | Online Inquiry |
KO04904 | CILK1 Knockout cell line (A549) | Human | CILK1 | 1:3~1:4 | Negative | Online Inquiry |
CILK1 Gene Knockout Cell Lines are genetically engineered cell lines in which the CILK1 gene has been inactivated using state-of-the-art CRISPR-Cas9 technology. These cell lines serve as invaluable tools for investigating the role of CILK1 in cellular processes, including cell proliferation, differentiation, and apoptosis. By offering a precise knockout of the gene, researchers can explore how the absence of CILK1 alters signaling pathways and impacts cellular function.
The key function of CILK1 knockout cell lines is to facilitate the dissection of gene function through loss-of-function analysis. The CILK1 protein is implicated in critical regulatory pathways, and its knockout allows scientists to observe resultant phenotypic changes. This provides insights into its role in physiological and pathological processes, essential for understanding disease mechanisms or therapeutic targets.
The scientific importance of the CILK1 knockout cell lines extends to various research fields, particularly cancer biology and regenerative medicine. Clinically, these cell lines can be applied in drug discovery, allowing for the screening of compounds that may target the pathways influenced by CILK1. Furthermore, they can be used to test the efficacy of potential therapies designed to modulate CILK1 function.
One of the unique advantages of our CILK1 Gene Knockout Cell Lines is the high specificity and efficiency of the gene editing, which minimizes off-target effects often encountered with alternative methods. This leads to reproducible results and enhances the credibility of experimental findings. Additionally, our cell lines are characterized by consistent performance across various applications, making them a reliable choice for researchers.
For researchers and clinicians striving to elucidate gene functions or develop novel therapeutics, the CILK1 Gene Knockout Cell Lines represent a critical asset. By providing a robust platform for experimentation, they empower users to generate meaningful data that can lead to significant advances in the understanding of gene regulation and disease.
Our company is committed to delivering high-quality biological tools backed by extensive expertise in molecular biology and genetic engineering. We ensure that our products not only meet but exceed the standards required by today’s rigorous scientific community.
Please note that all services are for research use only. Not intended for any clinical use.
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