Gene: CHST15
Official Full Name: carbohydrate sulfotransferase 15provided by HGNC
Gene Summary: Chondroitin sulfate (CS) is a glycosaminoglycan which is an important structural component of the extracellular matrix and which links to proteins to form proteoglycans. Chondroitin sulfate E (CS-E) is an isomer of chondroitin sulfate in which the C-4 and C-6 hydroxyl groups are sulfated. This gene encodes a type II transmembrane glycoprotein that acts as a sulfotransferase to transfer sulfate to the C-6 hydroxal group of chondroitin sulfate. This gene has also been identified as being co-expressed with RAG1 in B-cells and as potentially acting as a B-cell surface signaling receptor. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO22612 | CHST15 Knockout cell line (HeLa) | Human | CHST15 | 1:3~1:6 | Negative | Online Inquiry |
KO22613 | CHST15 Knockout cell line (HCT 116) | Human | CHST15 | 1:2~1:4 | Negative | Online Inquiry |
KO22614 | CHST15 Knockout cell line (HEK293) | Human | CHST15 | 1:3~1:6 | Negative | Online Inquiry |
KO22615 | CHST15 Knockout cell line (A549) | Human | CHST15 | 1:3~1:4 | Negative | Online Inquiry |
CHST15 Gene Knockout Cell Lines are a sophisticated biological tool designed for researchers investigating the functions of the carbohydrate sulfotransferase family, particularly CHST15, which plays a critical role in glycosaminoglycan biosynthesis and modification. By creating specific knockout variants of CHST15, these cell lines provide a unique platform for elucidating the gene's contribution to cellular processes, signaling pathways, and disease mechanisms.
The key function of CHST15 Gene Knockout Cell Lines lies in their ability to enable precise analysis of the impact of CHST15 absence on cellular behavior, metabolism, and gene expression. This is achieved through targeted gene editing techniques, typically employing CRISPR/Cas9 technology, which disrupts the gene's normal function, allowing researchers to study resultant phenotypic changes and investigate related biochemical pathways.
The scientific importance of these knockout cell lines is evident in their diverse applications in both fundamental research and clinical settings, including studies related to cancer biology, inflammation, and tissue regeneration. By using these cell lines, researchers can gain insights into the role of glycosaminoglycan modifications in cellular interactions and disease progression, thereby paving the way for the development of novel therapeutic strategies.
Compared to alternative models, such as overexpression systems or wild-type cell lines, CHST15 Gene Knockout Cell Lines offer a more physiologically relevant context for study, enabling the observation of gene function in the absence of confounding factors. Their specificity and reliability significantly enhance experimental reproducibility, providing a robust basis for scientific inquiry.
Researchers and clinicians benefit from these cell lines as they facilitate a deeper understanding of disease mechanisms, particularly those relating to developmental biology and pathology. This level of insight can drive advances in therapeutic interventions, making CHST15 Gene Knockout Cell Lines an invaluable asset in both academic and translational research.
Our company's commitment to developing high-quality, scientifically validated biological products ensures that you have access to reliable tools essential for cutting-edge research. By integrating advanced methodologies with a thorough understanding of biological systems, we empower scientists to explore the complexities of cellular function and disease.
Please note that all services are for research use only. Not intended for any clinical use.
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