Gene: CHRNB1
Official Full Name: cholinergic receptor nicotinic beta 1 subunitprovided by HGNC
Gene Summary: The muscle acetylcholine receptor is composed of five subunits: two alpha subunits and one beta, one gamma, and one delta subunit. This gene encodes the beta subunit of the acetylcholine receptor. The acetylcholine receptor changes conformation upon acetylcholine binding leading to the opening of an ion-conducting channel across the plasma membrane. Mutations in this gene are associated with slow-channel congenital myasthenic syndrome. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO38539 | CHRNB1 Knockout cell line (HeLa) | Human | CHRNB1 | 1:3~1:6 | Negative | Online Inquiry |
KO38540 | CHRNB1 Knockout cell line (HCT 116) | Human | CHRNB1 | 1:2~1:4 | Negative | Online Inquiry |
KO38541 | CHRNB1 Knockout cell line (HEK293) | Human | CHRNB1 | 1:3~1:6 | Negative | Online Inquiry |
KO38542 | CHRNB1 Knockout cell line (A549) | Human | CHRNB1 | 1:3~1:4 | Negative | Online Inquiry |
CHRNB1 Gene Knockout Cell Lines are specialized biological tools designed to investigate the functional role of the CHRNB1 gene, which encodes the beta-1 subunit of the nicotinic acetylcholine receptor. These cell lines are meticulously engineered through CRISPR/Cas9 gene editing technology to create a targeted disruption in the CHRNB1 gene, allowing researchers to explore the downstream effects of loss of function in a controlled environment.
The primary function of CHRNB1 Gene Knockout Cell Lines lies in their ability to replicate the absence of the beta-1 subunit, facilitating studies on neuronal signaling pathways and muscle contraction mechanisms where nicotinic receptors are implicated. By providing a model to assess functional changes in synaptic transmission, these cell lines help elucidate the physiological and pathological roles of nicotinic receptors in diseases such as myasthenia gravis and other neuromuscular disorders.
In research and clinical settings, these knockout cell lines have become invaluable in drug discovery, helping to identify potential therapeutic compounds that target specific receptor pathways. Additionally, they serve as effective models for understanding the genetic basis of diseases linked to the CHRNB1 gene, underpinning the development of genetically tailored treatments.
What sets CHRNB1 Gene Knockout Cell Lines apart from conventional cell models is their precision and specificity, obtained through state-of-the-art genome editing technologies. This precision minimizes off-target effects and enhances reproducibility in experimental outcomes, which are crucial for reliable data collection.
For researchers and clinicians, the value of CHRNB1 Gene Knockout Cell Lines is underscored by their potential to yield insights into receptor function and contribute to the advancement of therapeutic strategies in neurobiology and pharmacology. The ability to investigate a specific gene's role in a defined cellular context positions these knockout lines as pivotal tools in modern biomedical research.
At [Your Company Name], we leverage our extensive expertise in genetic engineering and cell biology to deliver cutting-edge products like the CHRNB1 Gene Knockout Cell Lines, ensuring our clients have access to high-quality research tools that facilitate innovative discoveries.
Please note that all services are for research use only. Not intended for any clinical use.
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