Home / CHPF Knockout Cell Lines

CHPF Knockout Cell Lines

Gene: CHPF

Official Full Name: chondroitin polymerizing factorprovided by HGNC

Gene Summary: Enables N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity and glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity. Involved in chondroitin sulfate biosynthetic process and chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process. Predicted to be located in Golgi membrane. Predicted to be active in Golgi apparatus. [provided by Alliance of Genome Resources, Apr 2025]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO18716 CHPF Knockout cell line (HeLa) Human CHPF 1:3~1:6 Negative Online Inquiry
KO18717 CHPF Knockout cell line (HCT 116) Human CHPF 1:2~1:4 Negative Online Inquiry
KO18718 CHPF Knockout cell line (HEK293) Human CHPF 1:3~1:6 Negative Online Inquiry
KO18719 CHPF Knockout cell line (A549) Human CHPF 1:3~1:4 Negative Online Inquiry

Background

CHPF Gene Knockout Cell Lines are genetically modified cell lines designed to specifically inhibit the expression of the CHPF gene, which encodes a protein implicated in the biosynthesis of glycosaminoglycans. These cell lines employ CRISPR/Cas9 technology to facilitate precise gene editing, effectively disrupting the CHPF gene and allowing researchers to study the resulting phenotypic changes. This novel tool enables thorough investigation into the biological roles of CHPF in cellular processes such as cell adhesion, proliferation, and extracellular matrix formation.

The primary mechanism of action involves the introduction of double-strand breaks in the target gene, leading to a loss-of-function mutation upon cellular repair. By analyzing the alterations in cellular behavior post-knockout, researchers can gain insights into the physiological and pathological roles of CHPF, particularly in conditions like cancer and cartilage-related disorders. The availability of these knockout cell lines provides an invaluable resource for both basic research and the development of therapeutic strategies targeting this gene.

The scientific significance of CHPF Gene Knockout Cell Lines lies in their applicability in various research domains, including molecular biology, oncology, and developmental biology. The product stands out in the marketplace due to its efficiency and reproducibility compared to conventional gene knockout methods, such as RNA interference or traditional homologous recombination. Additionally, the specificity of CRISPR/Cas9 minimizes off-target effects, ensuring more reliable experimental outcomes.

For researchers and clinicians aiming to explore the intricate mechanisms of glycosaminoglycans or to develop novel therapeutic interventions, CHPF Gene Knockout Cell Lines are an essential tool. Their unique selling points also include user-friendly protocols for cell line maintenance and high viability rates, making them an attractive option for laboratories focused on groundbreaking biological research.

As a trusted supplier in the field of genetic tools, our company brings extensive experience and a commitment to quality in biological product development. We strive to empower scientists with innovative solutions, ensuring their research efforts yield meaningful advancements in understanding and treating various diseases.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.