Gene: CHCHD3
Official Full Name: coiled-coil-helix-coiled-coil-helix domain containing 3provided by HGNC
Gene Summary: The protein encoded by this gene is an inner mitochondrial membrane scaffold protein. Absence of the encoded protein affects the structural integrity of mitochondrial cristae and leads to reductions in ATP production, cell growth, and oxygen consumption. This protein is part of the mitochondrial contact site and cristae organizing system (MICOS). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO18744 | CHCHD3 Knockout cell line (HeLa) | Human | CHCHD3 | 1:3~1:6 | Negative | Online Inquiry |
KO18745 | CHCHD3 Knockout cell line (HCT 116) | Human | CHCHD3 | 1:2~1:4 | Negative | Online Inquiry |
KO18746 | CHCHD3 Knockout cell line (HEK293) | Human | CHCHD3 | 1:3~1:6 | Negative | Online Inquiry |
CHCHD3 Gene Knockout Cell Lines are innovative cellular models specifically engineered to disrupt the CHCHD3 gene, which is implicated in various cellular processes including mitochondrial function and oxidative stress responses. By precisely knocking out this gene, these cell lines allow researchers to elucidate the role of CHCHD3 in pathophysiology, enabling detailed investigations into its contribution to disease mechanisms, such as neurodegenerative disorders and cancer progression.
The key function of the CHCHD3 Gene Knockout Cell Lines lies in their ability to provide a controlled environment to study gene function via loss-of-function methodologies. The knockout is achieved through CRISPR-Cas9 technology, which ensures precise targeting and efficiency in gene editing. This approach not only improves the accuracy of experimental results but also generates reproducible models that can be utilized across a variety of assays, including biochemical, molecular, and pharmacological studies.
In scientific research, these cell lines are invaluable tools for dissecting the molecular pathways associated with CHCHD3 dysregulation. They facilitate the development of novel therapeutic strategies targeting this gene and its downstream effects, which could lead to advancements in personalized medicine. Additionally, knockout models can be used for drug screening, providing a more relevant biological context for evaluating potential therapeutic agents.
Compared to conventional models that may involve the use of overexpression systems or transgenic animals, CHCHD3 Gene Knockout Cell Lines offer distinct advantages. They provide a more straightforward assessment of gene function and the biological consequences of specific gene deletions, reducing the complexity and potential artefacts that arise from compensatory mechanisms in live organisms.
For researchers and clinicians alike, the ability to manipulate CHCHD3 activity offers unprecedented insights into cellular responses and disease mechanisms. This specific model addresses critical gaps in current research methodologies, delivering high-quality results that can accelerate discovery and innovation within the field.
Our company specializes in advanced biological product development, combining cutting-edge gene editing techniques with a commitment to excellence in research tools. The CHCHD3 Gene Knockout Cell Lines are a testament to our expertise, reflecting our dedication to empowering the scientific community with reliable and effective biological models for groundbreaking research.
Please note that all services are for research use only. Not intended for any clinical use.
If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.
There is no product in your cart. |
CD Biosynsis is a leading customer-focused biotechnology company dedicated to providing high-quality products, comprehensive service packages, and tailored solutions to support and facilitate the applications of synthetic biology in a wide range of areas.