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CHAMP1 Knockout Cell Lines

Gene: CHAMP1

Official Full Name: chromosome alignment maintaining phosphoprotein 1provided by HGNC

Gene Summary: This gene encodes a zinc finger protein that functions as a regulator of chromosome segregation in mitosis. The encoded protein is required for correct alignment of chromosomes on the metaphase plate, and plays a role in maintaining the attachment of sister kinetochores to microtubules from opposite spindle poles. Mutations in this gene are associated with an autosomal dominant form of intellectual disability. [provided by RefSeq, Jul 2017]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO18747 CHAMP1 Knockout cell line (HeLa) Human CHAMP1 1:3~1:6 Negative Online Inquiry
KO18748 CHAMP1 Knockout cell line (HCT 116) Human CHAMP1 1:2~1:4 Negative Online Inquiry
KO18749 CHAMP1 Knockout cell line (HEK293) Human CHAMP1 1:3~1:6 Negative Online Inquiry
KO18750 CHAMP1 Knockout cell line (A549) Human CHAMP1 1:3~1:4 Negative Online Inquiry

Background

CHAMP1 Gene Knockout Cell Lines are specialized cellular models that have been genetically engineered to lack the CHAMP1 gene, which is implicated in various cellular processes, including chromosome stability, cell division, and DNA repair mechanisms. These knockout cell lines serve as critical tools for researchers studying the biological functions of CHAMP1 and its role in diseases such as cancer and neurological disorders.

The primary function of CHAMP1 Gene Knockout Cell Lines lies in their ability to disrupt normal gene expression, allowing researchers to investigate the consequences of CHAMP1 loss on cellular behavior. Mechanistically, the absence of CHAMP1 can lead to altered chromosomal dynamics and increased susceptibility to genomic instability, providing insights into the molecular pathways involved in tumorigenesis or other pathological conditions. By utilizing these cell lines, scientists can systematically explore the gene's functions in various biological contexts.

The scientific importance of CHAMP1 Gene Knockout Cell Lines is underscored by their applications in both basic research and therapeutic development. In research settings, they facilitate the understanding of gene function and its contributions to cellular physiology, while in clinical settings, their utility extends to drug testing and the development of targeted therapies. By elucidating the pathways affected by CHAMP1 deletion, these cell lines can inform strategies for overcoming therapeutic resistance in cancer treatments.

Unique selling points of CHAMP1 Gene Knockout Cell Lines include their high specificity and reproducibility compared to traditional RNA interference methods, which can produce off-target effects. Additionally, they provide a robust platform for creating stable, long-term experiments that reflect the physiological relevance of CHAMP1 knockout without the variability inherent in transient expression systems.

For researchers and clinicians aiming to enhance their understanding of genetic regulation in health and disease, CHAMP1 Gene Knockout Cell Lines represent an invaluable asset, supplying precise insights that can lead to novel interventions. With extensive expertise in genetic engineering and a commitment to providing high-quality biological products, our company is dedicated to supporting scientific advancement through innovative solutions like the CHAMP1 Gene Knockout Cell Lines.

Please note that all services are for research use only. Not intended for any clinical use.

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