Gene: CHAC1
Official Full Name: ChaC glutathione specific gamma-glutamylcyclotransferase 1provided by HGNC
Gene Summary: This gene encodes a member of the gamma-glutamylcyclotransferase family of proteins. The encoded protein has been shown to promote neuronal differentiation by deglycination of the Notch receptor, which prevents receptor maturation and inhibits Notch signaling. This protein may also play a role in the unfolded protein response, and in regulation of glutathione levels and oxidative balance in the cell. Elevated expression of this gene may indicate increased risk of cancer recurrence among breast and ovarian cancer patients. [provided by RefSeq, Sep 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO18755 | CHAC1 Knockout cell line (HeLa) | Human | CHAC1 | 1:3~1:6 | Negative | Online Inquiry |
KO18756 | CHAC1 Knockout cell line (HCT 116) | Human | CHAC1 | 1:2~1:4 | Negative | Online Inquiry |
KO18757 | CHAC1 Knockout cell line (HEK293) | Human | CHAC1 | 1:3~1:6 | Negative | Online Inquiry |
KO18758 | CHAC1 Knockout cell line (A549) | Human | CHAC1 | 1:3~1:4 | Negative | Online Inquiry |
CHAC1 Gene Knockout Cell Lines are specialized cellular models engineered to facilitate the investigation of the CHAC1 gene, which encodes a key enzyme involved in the regulation of cellular stress responses. These knockout cell lines are generated through precise genome-editing techniques, notably CRISPR-Cas9, resulting in the complete ablation of the CHAC1 gene. This disruption allows researchers to study the physiological and pathological roles of CHAC1 in a controlled environment, thereby enhancing our understanding of cellular mechanisms under stress conditions.
The primary function of CHAC1 involves influencing the balance of intracellular glutathione levels, critical for maintaining redox homeostasis and protecting against oxidative stress. By utilizing these knockout cell lines, scientists can elucidate pathways involved in cellular apoptosis, metabolism, and disease progression, especially in cancer and neurodegenerative disorders. Moreover, the ability to manipulate these cells provides a potent tool for high-throughput screening, enabling the identification of novel therapeutic targets and the development of innovative treatment strategies.
The scientific significance of CHAC1 Gene Knockout Cell Lines extends to both research and clinical settings, permitting exploration into potential drug interactions and gene therapy applications. These models offer a more biologically relevant platform compared to traditional cell lines, as they reflect the genetic and functional landscape of human cellular systems.
What sets our CHAC1 Gene Knockout Cell Lines apart from alternatives is their rigorous validation, ensuring the fidelity of the knockout, and the streamlined availability for immediate use in diverse research applications. Our cell lines are optimized for consistent performance in experiments, offering a robust solution for researchers aiming to generate reproducible data.
The value of our CHAC1 Gene Knockout Cell Lines is underscored by their potential to drive discovery in the fields of oncology and cellular biology. By integrating our products into your research, you leverage advanced technology and contribute to groundbreaking scientific developments. At our company, we pride ourselves on a commitment to quality and innovation, providing researchers with the tools necessary to push the boundaries of contemporary science.
Please note that all services are for research use only. Not intended for any clinical use.
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