Gene: CFLAR
Official Full Name: CASP8 and FADD like apoptosis regulatorprovided by HGNC
Gene Summary: The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8. However, the encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase-8. Several transcript variants encoding different isoforms have been found for this gene, and partial evidence for several more variants exists. [provided by RefSeq, Feb 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO00670 | CFLAR Knockout cell line (HeLa) | Human | CFLAR | 1:3~1:6 | Negative | Online Inquiry |
KO11108 | CFLAR Knockout cell line (HCT 116) | Human | CFLAR | 1:2~1:4 | Negative | Online Inquiry |
KO11109 | CFLAR Knockout cell line (HEK293) | Human | CFLAR | 1:3~1:6 | Negative | Online Inquiry |
CFLAR Gene Knockout Cell Lines are specialized cellular models engineered to lack the CFLAR gene, known for its role in inhibiting apoptosis and regulating cellular proliferation. These knockout cell lines provide researchers with a valuable tool to study the influence of CFLAR on various biological processes, including cancer progression, immune response, and cellular stress pathways. By eliminating the CFLAR gene, these cell lines facilitate the observation of altered signaling pathways and metabolic changes, offering insights into the pathological roles CFLAR plays in diseases.
The primary function of CFLAR Gene Knockout Cell Lines is to enable the effective investigation of the biological consequences that arise from the absence of CFLAR expression. By utilizing advanced CRISPR/Cas9 genome editing techniques, these cell lines possess high specificity and efficiency in gene disruption, minimizing off-target effects. Their use can lead to the identification of novel therapeutic targets by elucidating the molecular mechanisms underlying conditions such as tumors or immune disorders.
Scientifically, the presence of CFLAR Gene Knockout Cell Lines within research and clinical settings significantly enhances the understanding of apoptosis modulation and cell survival mechanisms. Their implications extend to therapeutic development, particularly in oncology where inhibiting CFLAR may enhance tumor cell sensitivity to chemotherapy and immunotherapies.
Compared to traditional cell lines, these knockout models offer distinct advantages, including improved experimental precision, reproducibility, and the ability to model disease mechanisms more accurately. Unlike alternative cell models, which may have residual CFLAR activity, our dedicated CFLAR knockouts present a clean genetic background maximized for thorough analysis.
For researchers, clinicians, and biopharmaceutical companies, the CFLAR Gene Knockout Cell Lines represent a critical innovation in studying apoptosis and treatment strategies. Their unique capability to delineate the role of CFLAR in cellular physiology stands as a compelling reason for their adoption in cutting-edge research.
Our company is committed to excellence in developing high-quality biological models tailored for research purposes. With expertise in genome editing technologies and a robust understanding of cellular biology, we strive to provide superior products that propel scientific advancements and support the global research community.
Please note that all services are for research use only. Not intended for any clinical use.
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