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CERS2 Knockout Cell Lines

Gene: CERS2

Official Full Name: ceramide synthase 2provided by HGNC

Gene Summary: This gene encodes a protein that has sequence similarity to yeast longevity assurance gene 1. Mutation or overexpression of the related gene in yeast has been shown to alter yeast lifespan. The human protein may play a role in the regulation of cell growth. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO07678 CERS2 Knockout cell line (HeLa) Human CERS2 1:3~1:6 Negative Online Inquiry
KO07679 CERS2 Knockout cell line (HCT 116) Human CERS2 1:2~1:4 Negative Online Inquiry
KO07680 CERS2 Knockout cell line (HEK293) Human CERS2 1:3~1:6 Negative Online Inquiry
KO07681 CERS2 Knockout cell line (A549) Human CERS2 1:3~1:4 Negative Online Inquiry

Background

CERS2 Gene Knockout Cell Lines are genetically modified cellular models in which the Ceramide Synthase 2 (CERS2) gene has been selectively disrupted or "knocked out." This product is essential for studying the functional implications of CERS2 in a variety of biological processes, particularly in lipid metabolism, cell signaling, and cell differentiation. These cell lines offer a precise tool for researchers aiming to elucidate the role of CERS2 in health and disease, thereby contributing to a deeper understanding of conditions such as cancer, metabolic disorders, and neurodegenerative diseases.

The primary mechanism of action in CERS2 gene knockout models involves the absence of the CERS2 protein, leading to altered levels of ceramide and sphingolipid metabolism. This knockout allows researchers to directly observe downstream physiological effects, providing insights into how altered lipid signaling pathways can influence cellular behavior and contribute to pathological states. By utilizing these cell lines, scientists can conduct high-throughput screenings, gene expression analyses, and pathway elucidation studies that would otherwise be challenging in wild-type cellular environments.

In both research and clinical settings, CERS2 Gene Knockout Cell Lines are invaluable for investigating potential therapeutic targets and biomarker discovery. Their use in the development of drugs aimed at modulating sphingolipid pathways illustrates their practical implications, particularly in the area of personalized medicine, where understanding individual genetic variations can lead to tailored treatments.

Compared to alternative models, such as transient knockdown or overexpression systems, these stable knockout lines provide more consistent and reliable phenotypic data, enabling researchers to draw robust conclusions based on reproducible results. Furthermore, their ease of use in various experimental setups streamlines workflows and enhances the productivity of research efforts.

The value of CERS2 Gene Knockout Cell Lines lies not only in their functional capabilities but also in the expertise and dedication of our company to provide high-quality, customizable biological products. With a commitment to advancing biological research, we ensure that our products are backed by rigorous validation and robust support, empowering researchers and clinicians to achieve their scientific objectives with confidence.

Please note that all services are for research use only. Not intended for any clinical use.

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