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CEP120 Knockout Cell Lines

Gene: CEP120

Official Full Name: centrosomal protein 120provided by HGNC

Gene Summary: This gene encodes a protein that functions in the microtubule-dependent coupling of the nucleus and the centrosome. A similar protein in mouse plays a role in both interkinetic nuclear migration, which is a characteristic pattern of nuclear movement in neural progenitors, and in neural progenitor self-renewal. Mutations in this gene are predicted to result in neurogenic defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO21538 CEP120 Knockout cell line (HeLa) Human CEP120 1:3~1:6 Negative Online Inquiry
KO21539 CEP120 Knockout cell line (HCT 116) Human CEP120 1:2~1:4 Negative Online Inquiry
KO21540 CEP120 Knockout cell line (HEK293) Human CEP120 1:3~1:6 Negative Online Inquiry
KO21541 CEP120 Knockout cell line (A549) Human CEP120 1:3~1:4 Negative Online Inquiry

Background

CEP120 Gene Knockout Cell Lines are meticulously engineered cellular models designed to facilitate in-depth exploration of the CEP120 gene’s function and its role in various biological processes, especially in the context of cilia-related disorders. These knockout cell lines are created using advanced CRISPR/Cas9 technology, which enables precise editing of the genome to disrupt the CEP120 gene, effectively providing a powerful tool for genetic studies.

The primary function of these cell lines is to allow researchers to investigate the phenotypic and molecular consequences of CEP120 gene loss. CEP120 is critical for cilia formation and maintenance, and its knockout can elucidate pathways involved in primary ciliary dyskinesia, polycystic kidney disease, and neurodevelopmental disorders. Researchers can utilize these cell lines to perform functional assays, analyze cellular signaling pathways, and study changes in protein expression, contributing valuable insights into disease mechanisms and potential therapeutic targets.

The scientific importance of CEP120 Gene Knockout Cell Lines extends to both basic research and clinical applications. In laboratories, they can serve as models for drug screening, allowing for the identification of compounds that can potentially correct or ameliorate the phenotypic consequences of CEP120 deficits. Clinically, findings derived from these studies can inform the development of targeted gene therapies or biomarker identification for affected patient populations.

What sets our CEP120 Gene Knockout Cell Lines apart from alternatives is their verified gene editing efficiency and expression control, allowing for reproducible and reliable results. Our products come with comprehensive documentation on genotyping assays and functional validations, ensuring that researchers can trust in the quality of the models they are working with.

In summary, our CEP120 Gene Knockout Cell Lines are indispensable for researchers and clinicians looking to deepen their understanding of cilia biology and related disorders. With our extensive experience in the development of biological products, we offer expertise and support to empower your research endeavors and advance scientific discovery.

Please note that all services are for research use only. Not intended for any clinical use.

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