Gene: CEP104
Official Full Name: centrosomal protein 104provided by HGNC
Gene Summary: This gene encodes a centrosomal protein required for ciliogenesis and for ciliary tip structural integrity. The mammalian protein contains three amino-terminal hydrophobic domains, two glycosylation sites, four cysteine-rich motifs, and two regions with homology to the glutamate receptor ionotropic, NMDA 1 protein. During ciliogenesis, the encoded protein translocates from the distal tips of the centrioles to the tip of the elongating cilium. Knockdown of the protein in human retinal pigment cells results in severe defects in ciliogenesis with structural deformities at the ciliary tips. Allelic variants of this gene are associated with the autosomal-recessive disorder Joubert syndrome, which is characterized by a distinctive mid-hindbrain and cerebellar malformation, oculomotor apraxia, irregular breathing, developmental delay, and ataxia. [provided by RefSeq, Feb 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO32850 | CEP104 Knockout cell line (HeLa) | Human | CEP104 | 1:3~1:6 | Negative | Online Inquiry |
KO32851 | CEP104 Knockout cell line (HCT 116) | Human | CEP104 | 1:2~1:4 | Negative | Online Inquiry |
KO32852 | CEP104 Knockout cell line (HEK293) | Human | CEP104 | 1:3~1:6 | Negative | Online Inquiry |
KO32853 | CEP104 Knockout cell line (A549) | Human | CEP104 | 1:3~1:4 | Negative | Online Inquiry |
CEP104 Gene Knockout Cell Lines are specialized cell lines engineered to lack the CEP104 gene, a critical gene associated with ciliogenesis and cellular signaling pathways. These knockout cell lines serve as indispensable tools for investigating the functional role of CEP104 in various biological processes, particularly in the study of cilia-related diseases and cellular development.
The key function of CEP104 Gene Knockout Cell Lines involves the disruption of the normal CEP104 gene expression, allowing researchers to analyze the resulting phenotypic and molecular changes. The mechanism behind their utility lies in the ability to observe alterations in cellular behavior, signaling cascades, and responses to environmental stimuli that occur in the absence of CEP104. This allows for elucidation of its role in cilia formation, which is crucial for maintaining cellular homeostasis and signaling.
Scientifically, these cell lines are valuable in both research and clinical settings, particularly for studies related to primary ciliary dyskinesia, polycystic kidney disease, and other disorders linked to ciliary dysfunction. By using these knockout lines, researchers can create a clearer understanding of disease mechanisms, paving the way for potential therapeutic interventions.
What sets CEP104 Gene Knockout Cell Lines apart from alternative products is their superior specificity and reliability in gene disruption, coupled with robust supporting data that demonstrate their efficacy in various experimental setups. They offer a consistent platform for experiments that require precise genetic manipulation, providing reliable and reproducible results that are essential for cutting-edge research.
In summary, CEP104 Gene Knockout Cell Lines are a valuable asset for researchers and clinicians looking to unlock the complexities of ciliopathies and enhance gene function studies. With extensive expertise in cellular biology and a commitment to quality, our company ensures that these products meet the highest standards of scientific rigor, enabling advances in biological research and potential clinical applications.
Please note that all services are for research use only. Not intended for any clinical use.
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