Gene: CDCA4
Official Full Name: cell division cycle associated 4provided by HGNC
Gene Summary: This gene encodes a protein that belongs to the E2F family of transcription factors. This protein regulates E2F-dependent transcriptional activation and cell proliferation, mainly through the E2F/retinoblastoma protein pathway. It also functions in the regulation of JUN oncogene expression. This protein shows distinctive nuclear-mitotic apparatus distribution, it is involved in spindle organization from prometaphase, and may also play a role as a midzone factor involved in chromosome segregation or cytokinesis. Two alternatively spliced transcript variants encoding the same protein have been noted for this gene. Two pseudogenes have also been identified on chromosome 1. [provided by RefSeq, May 2014]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO02427 | CDCA4 Knockout cell line (HeLa) | Human | CDCA4 | 1:3~1:6 | Negative | Online Inquiry |
KO02428 | CDCA4 Knockout cell line (HCT 116) | Human | CDCA4 | 1:2~1:4 | Negative | Online Inquiry |
KO02429 | CDCA4 Knockout cell line (HEK293) | Human | CDCA4 | 1:3~1:6 | Negative | Online Inquiry |
KO02430 | CDCA4 Knockout cell line (A549) | Human | CDCA4 | 1:3~1:4 | Negative | Online Inquiry |
CDCA4 Gene Knockout Cell Lines are genetically engineered cell lines specifically designed for the detailed study of the cell division control protein 4 (CDCA4) gene, which plays a critical role in regulating the cell cycle and ensuring genomic integrity. By employing CRISPR/Cas9 technology, our product facilitates the precise knockout of the CDCA4 gene, allowing researchers to investigate the gene’s function in cellular proliferation, DNA repair mechanisms, and tumorigenesis.
The primary function of these cell lines lies in their ability to mimic specific pathological conditions observed in cancer and other proliferative disorders. By depleting CDCA4, researchers can analyze downstream effects on cell cycle regulation, apoptosis, and other crucial cellular processes. Additionally, these knockout cell lines provide a valuable tool for screening potential therapeutic targets and evaluating the efficacy of novel pharmaceuticals aimed at restoring normal cell cycle regulation.
The scientific importance of CDCA4 Gene Knockout Cell Lines extends to both academic research and clinical applications. In laboratory settings, these cell lines are instrumental for understanding the molecular pathways that govern cell division, making them vital for studies focused on cancer biology, regenerative medicine, and genetic disorders. Furthermore, their use in preclinical studies can accelerate drug development initiatives targeting cell cycle dysregulation, which is prevalent in various malignancies.
What sets our product apart from alternatives is the robustness of the knockout achieved, along with our commitment to rigorous characterization, ensuring researchers receive consistently high-quality cell lines with validated knockout efficiency. This enhances experimental reproducibility and reliability, making our cell lines exceptionally valuable for both routine laboratory studies and high-impact research projects.
In summary, CDCA4 Gene Knockout Cell Lines represent an indispensable resource for researchers and clinicians alike, contributing significantly to the advancement of knowledge in cell biology and therapeutic development. Our company, renowned for its expertise in providing high-quality biological products, is dedicated to supporting scientific discovery and innovation, empowering researchers with the tools necessary to unravel the complexities of cellular mechanisms.
Please note that all services are for research use only. Not intended for any clinical use.
If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.
There is no product in your cart. |
CD Biosynsis is a leading customer-focused biotechnology company dedicated to providing high-quality products, comprehensive service packages, and tailored solutions to support and facilitate the applications of synthetic biology in a wide range of areas.