Gene: CD163L1
Official Full Name: CD163 molecule like 1provided by HGNC
Gene Summary: This gene encodes a member of the scavenger receptor cysteine-rich (SRCR) superfamily. Members of this family are secreted or membrane-anchored proteins mainly found in cells associated with the immune system. The SRCR family is defined by a 100-110 amino acid SRCR domain, which may mediate protein-protein interaction and ligand binding. The encoded protein contains twelve SRCR domains, a transmembrane region and a cytoplasmic domain. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO18899 | CD163L1 Knockout cell line (HeLa) | Human | CD163L1 | 1:3~1:6 | Negative | Online Inquiry |
KO18900 | CD163L1 Knockout cell line (HCT 116) | Human | CD163L1 | 1:2~1:4 | Negative | Online Inquiry |
CD163L1 Gene Knockout Cell Lines represent a cutting-edge tool in molecular biology designed to facilitate advanced research into the role of the CD163L1 gene in various physiological and pathological processes. These cell lines have been engineered using CRISPR-Cas9 technology to create a null mutation in the CD163L1 gene, effectively eliminating its expression. This targeted alteration allows researchers to investigate the gene's biological functions, signaling pathways, and interactions with other cellular components.
The key mechanism behind CD163L1 knockout cell lines is the CRISPR-Cas9 system, which employs RNA-guided endonucleases to induce precise double-strand breaks in the DNA at the target gene locus. By capitalizing on this natural repair process, the cell’s intrinsic mechanisms often lead to random insertions or deletions that disrupt the gene's function. This specific knockout enables researchers to analyze phenotypic changes, assess cellular responses, and pinpoint alterations in pathways that may contribute to diseases, especially in fields like immunology, oncology, and regenerative medicine.
In the context of research or clinical applications, CD163L1 is closely linked to inflammation and immune regulation, making these cell lines invaluable for studying autoimmune disorders, cancer immunotherapy, and the development of new therapeutic strategies. By utilizing these knockout cell lines, scientists can develop better experimental models that yield insight into disease mechanisms, ultimately driving innovation in treatment design.
Compared to traditional knockdown assays and other gene editing technologies, the CD163L1 Gene Knockout Cell Lines offer a more durable and complete disruption of gene function, providing researchers with a robust platform for studying cellular dynamics. Moreover, the ability to produce homogeneous cell populations enhances experimental reproducibility, making results more reliable.
Ultimately, the value of CD163L1 Gene Knockout Cell Lines lies in their ability to accelerate scientific discovery and facilitate advancements in medical research and therapeutic applications. Our company prides itself on its commitment to developing high-quality biological products, supported by extensive expertise in gene editing technologies and a deep understanding of the underlying biology. With our dedication to excellence, we empower researchers and clinicians to push the boundaries of science and improve human health outcomes.
Please note that all services are for research use only. Not intended for any clinical use.
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