Gene: CD151
Official Full Name: CD151 molecule (Raph blood group)provided by HGNC
Gene Summary: The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. This protein enhances cell motility, invasion and metastasis of cancer cells. Multiple alternatively spliced transcript variants that encode the same protein have been described for this gene. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO05564 | CD151 Knockout cell line (HeLa) | Human | CD151 | 1:3~1:6 | Negative | Online Inquiry |
KO05565 | CD151 Knockout cell line (HCT 116) | Human | CD151 | 1:2~1:4 | Negative | Online Inquiry |
KO05566 | CD151 Knockout cell line (HEK293) | Human | CD151 | 1:3~1:6 | Negative | Online Inquiry |
KO05567 | CD151 Knockout cell line (A549) | Human | CD151 | 1:3~1:4 | Negative | Online Inquiry |
CD151 Gene Knockout Cell Lines are specialized cellular models that have undergone genetic modification to disrupt the expression of the CD151 gene. CD151, a member of the tetraspanin family, plays a pivotal role in various cellular processes, including cell adhesion, motility, and signaling pathways that are crucial for cancer progression and metastasis. The knockout of this gene allows researchers to investigate the specific roles and contributions of CD151 in cellular environments, making it a vital tool for dissecting complex biological interactions in both normal and pathological contexts.
These cell lines function by utilizing advanced gene-editing techniques, such as CRISPR-Cas9, to create precise deletions or modifications in the CD151 gene. This targeted approach enables scientists to observe the phenotypic consequences of the CD151 loss, including altered cell morphology, changes in proliferation rates, and variations in the signaling cascades that promote invasion or migration, which are often implicated in tumor biology.
The scientific importance of CD151 Gene Knockout Cell Lines extends beyond basic research; they are instrumental in preclinical studies aimed at developing therapeutic strategies for cancer. By understanding how CD151 influences tumor behavior, researchers can identify potential drug targets or pathways for intervention. Additionally, these cell lines can facilitate the study of CD151's role in immune response, providing insights into potential autoimmune diseases and therapeutic applications.
What sets our CD151 Gene Knockout Cell Lines apart from alternatives is their validated and reproducible genetic modifications, along with rigorous quality control measures. Our cells are extensively characterized to ensure that they reflect true knockout phenotypes, reducing variability in experimental outcomes. This reliability is crucial for researchers in both academic and clinical settings who require consistent models for their studies.
For researchers, clinicians, and biopharmaceutical companies seeking to advance their understanding of CD151-related processes, these knockout cell lines represent an invaluable resource. Our commitment to excellence in cell line development and characterization stems from years of expertise in the field of genetic engineering and cellular biology, ensuring that our customers receive only the highest quality products for their research and therapeutic endeavors.
Please note that all services are for research use only. Not intended for any clinical use.
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