Gene: CCNL2
Official Full Name: cyclin L2provided by HGNC
Gene Summary: The protein encoded by this gene belongs to the cyclin family. Through its interaction with several proteins, such as RNA polymerase II, splicing factors, and cyclin-dependent kinases, this protein functions as a regulator of the pre-mRNA splicing process, as well as in inducing apoptosis by modulating the expression of apoptotic and antiapoptotic proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO05992 | CCNL2 Knockout cell line (HeLa) | Human | CCNL2 | 1:3~1:6 | Negative | Online Inquiry |
KO05993 | CCNL2 Knockout cell line (HCT 116) | Human | CCNL2 | 1:2~1:4 | Negative | Online Inquiry |
KO05994 | CCNL2 Knockout cell line (HEK293) | Human | CCNL2 | 1:3~1:6 | Negative | Online Inquiry |
KO05995 | CCNL2 Knockout cell line (A549) | Human | CCNL2 | 1:3~1:4 | Negative | Online Inquiry |
CCNL2 Gene Knockout Cell Lines are genetically engineered cell lines developed for the specific purpose of studying the role of the cyclin L2 (CCNL2) gene in cellular processes and disease mechanisms. The knockout of this gene eliminates its expression, thus allowing researchers to investigate the physiological and pathological outcomes of CCNL2 absence. These cell lines serve as invaluable tools for dissecting CCNL2's function in various biological contexts, contributing to our understanding of gene regulation, cell cycle progression, and potential links to cancer biology.
The primary mechanism at play is the targeted disruption of the CCNL2 gene using CRISPR-Cas9 technology, a revolutionary genome editing tool that offers high specificity and efficiency. By creating these knockout cell lines, researchers can explore the downstream effects of CCNL2 deficiency, including alterations in RNA splicing, transcript stability, and signaling pathways that may be disrupted in diseases such as cancer and genetic disorders.
The scientific importance of CCNL2 Gene Knockout Cell Lines is underscored by their application in both basic research and translational medicine. In research settings, they enable the elucidation of gene function, while in clinical applications, they hold the potential for developing targeted therapies based on the specific pathways affected by CCNL2 regulation.
When compared to alternatives, such as RNA interference models that may produce incomplete knockdown or off-target effects, CCNL2 knockout cell lines provide a more reliable and stable method for gene functional studies. The ability to consistently produce pure populations of cells completely lacking the CCNL2 gene allows for reproducible and scalable experiments, paving the way for more robust scientific discoveries.
For researchers and clinicians alike, the value of CCNL2 Gene Knockout Cell Lines lies in their ability to generate clear insights into the molecular underpinnings of diseases associated with CCNL2 dysfunction. This understanding can ultimately lead to innovations in therapeutic strategies and diagnostics that improve patient outcomes.
By offering these specialized cell lines, our company leverages extensive expertise in genetic engineering and molecular biology, ensuring that our products meet rigorous scientific standards and support transformative research endeavors in the life sciences.
Please note that all services are for research use only. Not intended for any clinical use.
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