Gene: CCNG2
Official Full Name: cyclin G2provided by HGNC
Gene Summary: The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The 8 species of cyclins reported in mammals, cyclins A through H, share a conserved amino acid sequence of about 90 residues called the cyclin box. The amino acid sequence of cyclin G is well conserved among mammals. The nucleotide sequence of cyclin G1 and cyclin G2 are 53% identical. Unlike cyclin G1, cyclin G2 contains a C-terminal PEST protein destabilization motif, suggesting that cyclin G2 expression is tightly regulated through the cell cycle. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO08185 | CCNG2 Knockout cell line (HeLa) | Human | CCNG2 | 1:3~1:6 | Negative | Online Inquiry |
KO08186 | CCNG2 Knockout cell line (HCT 116) | Human | CCNG2 | 1:2~1:4 | Negative | Online Inquiry |
KO08187 | CCNG2 Knockout cell line (HEK293) | Human | CCNG2 | 1:3~1:6 | Negative | Online Inquiry |
KO08188 | CCNG2 Knockout cell line (A549) | Human | CCNG2 | 1:3~1:4 | Negative | Online Inquiry |
CCNG2 Gene Knockout Cell Lines are genetically engineered cellular models designed specifically to elucidate the functions of the cyclin G2 (CCNG2) gene, which plays a critical role in cell cycle regulation and various cellular processes. These cell lines are created using advanced CRISPR-Cas9 gene editing technology, resulting in a precise knockout of the CCNG2 gene, offering researchers a powerful tool for study.
The primary function of these cell lines is to facilitate investigations into the regulatory mechanisms of cell proliferation, differentiation, and apoptosis. By utilizing these knockout models, researchers can effectively analyze the phenotypic changes that occur in the absence of CCNG2, thereby gaining insights into its role in tumorigenesis, cellular response to stress, and overall cellular health. The mechanistic understanding gleaned from these studies is invaluable for cancer research, as alterations in CCNG2 expression are linked to various malignancies.
In scientific research and clinical applications, CCNG2 gene knockout cell lines serve as essential platforms for drug development, biomarker discovery, and understanding disease mechanisms. Their versatility enables scientists to conduct experiments across multiple areas, including cancer biology, regenerative medicine, and neurobiology, leading to potential breakthroughs in therapeutic strategies.
Compared to alternative gene knockout models, CCNG2 gene knockout cell lines offer enhanced specificity and reproducibility, owing to their precise genetic modification. This targeted approach minimizes off-target effects, allowing for more accurate interpretations of experimental data. Additionally, these cell lines can be cultured in various environments and conditions, making them adaptable to numerous laboratory settings.
The value of CCNG2 gene knockout cell lines lies in their ability to advance our understanding of fundamental biological processes and the molecular underpinnings of disease, ultimately contributing to the development of innovative diagnostics and treatments. Researchers and clinicians benefit from using these models, as they provide a rigorous and reliable means of dissecting gene function.
Our company, specializing in cutting-edge genetic engineering technologies, is committed to providing high-quality biological products. Our CCNG2 gene knockout cell lines exemplify our dedication to supporting the scientific community by enabling groundbreaking research and fostering advancements in the field.
Please note that all services are for research use only. Not intended for any clinical use.
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