Gene: CCNE2
Official Full Name: cyclin E2provided by HGNC
Gene Summary: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2. This cyclin has been shown to specifically interact with CIP/KIP family of CDK inhibitors, and plays a role in cell cycle G1/S transition. The expression of this gene peaks at the G1-S phase and exhibits a pattern of tissue specificity distinct from that of cyclin E1. A significantly increased expression level of this gene was observed in tumor-derived cells. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO10433 | CCNE2 Knockout cell line (HeLa) | Human | CCNE2 | 1:3~1:6 | Negative | Online Inquiry |
KO10434 | CCNE2 Knockout cell line (HCT 116) | Human | CCNE2 | 1:2~1:4 | Negative | Online Inquiry |
KO10435 | CCNE2 Knockout cell line (HEK293) | Human | CCNE2 | 1:3~1:6 | Negative | Online Inquiry |
KO10436 | CCNE2 Knockout cell line (A549) | Human | CCNE2 | 1:3~1:4 | Negative | Online Inquiry |
CCNE2 Gene Knockout Cell Lines are a sophisticated biological product designed for advanced research in cellular and molecular biology, specifically targeting the cyclin E2 (CCNE2) gene. These cell lines have been engineered using CRISPR-Cas9 technology to create a complete knockout of the CCNE2 gene, enabling researchers to investigate the implications of CCNE2 loss on cell cycle regulation, proliferation, and various tumorigenic processes.
The primary function of the CCNE2 Gene Knockout Cell Lines is to provide a valuable tool for studying the role of cyclin E2 in cellular mechanisms. CCNE2 is a critical regulator of the G1/S phase transition in the cell cycle, and its dysregulation is linked to various cancers. By utilizing these knockout cell lines, researchers can explore how the absence of CCNE2 affects cell cycle dynamics, gene expression profiles, and signaling pathways involved in cancer progression.
In scientific research and clinical applications, the ability to precisely manipulate gene function is essential for unraveling pathogenic mechanisms and developing targeted therapies. The CCNE2 Gene Knockout Cell Lines contribute significantly to the understanding of tumor biology and could facilitate the identification of novel therapeutic targets in cancers characterized by CCNE2 overexpression or dysfunction.
What sets our CCNE2 Gene Knockout Cell Lines apart from alternatives is the precision and reliability of the CRISPR-Cas9 methodology employed during their generation, ensuring high efficiency and reproducibility in experimental outcomes. Unlike traditional methods that may produce off-target effects or incomplete knockouts, our products provide a robust platform for accurate and reliable research.
For researchers and clinicians focused on cancer biology or cell cycle regulation, these knockout cell lines represent an indispensable resource. Their availability enhances experimental versatility, paving the way for innovative studies and breakthroughs in understanding cancer biology.
With a commitment to excellence in the field of genetic engineering and cell biology, our company stands at the forefront of scientific innovation, offering not only CCNE2 Gene Knockout Cell Lines but a comprehensive portfolio of high-quality biological products tailored to meet the needs of today's researchers.
Please note that all services are for research use only. Not intended for any clinical use.
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