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CCNB3 Knockout Cell Lines

Gene: CCNB3

Official Full Name: cyclin B3provided by HGNC

Gene Summary: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as positive regulators of cyclin-dependent kinases (CDKs), and thereby play an essential role in the control of the cell cycle. Different cyclins exhibit distinct expression and degradation patterns, which contribute to the temporal coordination of each mitotic event. Studies of similar genes in chicken and drosophila suggest that this cyclin may associate with CDC2 and CDK2 kinases, and may be required for proper spindle reorganization and restoration of the interphase nucleus. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO08189 CCNB3 Knockout cell line (HCT 116) Human CCNB3 1:2~1:4 Negative Online Inquiry
KO08190 CCNB3 Knockout cell line (A549) Human CCNB3 1:3~1:4 Negative Online Inquiry

Background

CCNB3 Gene Knockout Cell Lines are engineered cellular models that have had the CCNB3 gene specifically disrupted, providing a powerful tool for investigating the molecular underpinnings of cell cycle regulation. CCNB3, known as Cyclin B3, is predominantly involved in the regulation of the cell cycle, particularly in the transition of cells from metaphase to anaphase. By creating knockout cell lines, researchers can effectively observe the resultant phenotypic changes and unravel the gene's role in cellular processes such as proliferation, differentiation, and apoptosis.

The primary function of these knockout cell lines is to facilitate comprehensive studies on cell cycle dynamics and related pathways. By removing the CCNB3 gene, researchers can examine the compensatory mechanisms that may come into play, allowing for a more in-depth understanding of cell cycle regulation. Utilizing these cell lines in assays can provide insights into potential therapeutic targets for conditions such as cancer, where dysregulation of the cell cycle is a hallmark feature.

The scientific importance of CCNB3 Gene Knockout Cell Lines extends to various applications in both research and clinical settings. These models are invaluable for studying the effects of CCNB3 on cellular responses to drugs, identifying biomarkers for cellular progression, and testing novel therapeutic interventions. They serve as a critical resource for cancer biologists in delineating the functional effects of specific cyclins in tumorigenesis.

What sets our CCNB3 Gene Knockout Cell Lines apart from alternatives is the precision of the knockout, verified through CRISPR/Cas9 or similar methodologies, ensuring a high specificity with minimal off-target effects. This enhances the reliability of experimental outcomes, a crucial factor in scientific discovery. Additionally, we provide extensive support for users, including detailed protocols and troubleshooting guides, to maximize research efficacy.

Our commitment to advancing cellular biology research is underscored by our expertise in developing high-quality biological products tailored for the evolving needs of researchers and clinicians. By choosing our CCNB3 Gene Knockout Cell Lines, users gain access to a premier resource that can significantly enhance their investigative capabilities and contribute to groundbreaking discoveries.

Please note that all services are for research use only. Not intended for any clinical use.

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