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CCL28 Knockout Cell Lines

Gene: CCL28

Official Full Name: C-C motif chemokine ligand 28provided by HGNC

Gene Summary: This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for resting CD4 or CD8 T cells and eosinophils. The product of this gene binds to chemokine receptors CCR3 and CCR10. This chemokine may play a role in the physiology of extracutaneous epithelial tissues, including diverse mucosal organs. Multiple transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO18916 CCL28 Knockout cell line (HeLa) Human CCL28 1:3~1:6 Negative Online Inquiry

Background

CCL28 Gene Knockout Cell Lines are specifically engineered cellular models created by targeting and disrupting the CCL28 gene, which encodes a chemokine primarily involved in immune cell recruitment and mucosal immunity. This product serves as a powerful tool for researchers investigating the role of CCL28 in various physiological and pathological contexts, including tumor biology and inflammatory diseases.

The key function of these knockout cell lines is to provide a controlled environment for studying the mechanistic pathways influenced by CCL28. By eliminating the gene's expression, researchers can observe the resultant biochemical and cellular changes, allowing for a better understanding of CCL28’s contributions to immune responses and its potential interactions with other signaling molecules. This can include studying altered chemotactic responses, cytokine production, and cell proliferation behaviors.

The scientific importance of CCL28 Gene Knockout Cell Lines extends into various research and clinical applications. They are especially relevant in cancer research, where understanding immune evasion tactics used by tumors is critical. Additionally, these cell lines facilitate studies in autoimmune and chronic inflammatory diseases, leading to insights that can influence therapeutic strategies.

In comparison to alternative models such as wild-type cell lines or pharmacological inhibition methods, CCL28 Gene Knockout Cell Lines provide a more precise and genetically defined framework for research. This specificity allows for clearer delineation of CCL28's biological roles without the confounding effects inherent to other approaches.

The inherent value of CCL28 Gene Knockout Cell Lines lies in their ability to enhance research understanding and accelerate discovery in immunological research. By utilizing these models, researchers and clinicians can develop more targeted interventions with potentially better outcomes in disease management and treatment.

Our company is dedicated to providing high-quality genetic tools and solutions for biological research, backed by extensive expertise and a commitment to advancing scientific discovery. CCL28 Gene Knockout Cell Lines represent our innovative approach to support researchers in uncovering the complexities of immune system function.

Please note that all services are for research use only. Not intended for any clinical use.

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