Gene: CASP8
Official Full Name: caspase 8provided by HGNC
Gene Summary: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO00534 | CASP8 Knockout cell line (HeLa) | Human | CASP8 | 1:3~1:6 | Negative | Online Inquiry |
KO08343 | CASP8 Knockout cell line (HCT 116) | Human | CASP8 | 1:2~1:4 | Negative | Online Inquiry |
KO08344 | CASP8 Knockout cell line (HEK293) | Human | CASP8 | 1:3~1:6 | Negative | Online Inquiry |
KO08345 | CASP8 Knockout cell line (A549) | Human | CASP8 | 1:3~1:4 | Negative | Online Inquiry |
CASP8 Gene Knockout Cell Lines are genetically engineered cellular models specifically designed to investigate the biological role of caspase 8 in apoptosis, immune response, and various disease states. These cell lines feature a targeted deletion of the CASP8 gene, effectively eliminating the expression of this critical enzyme involved in the initiation of extrinsic apoptosis signaling pathways. Understanding the mechanisms governed by CASP8 is pivotal in both fundamental biology and therapeutic development, making these cell lines invaluable to researchers.
The primary function of the CASP8 Gene Knockout Cell Lines is to facilitate the exploration of caspase 8's role in programmed cell death and its implications in cancer, autoimmune disorders, and infectious diseases. With the absence of caspase 8, researchers can analyze compensatory apoptotic pathways, assess cell viability under different stress conditions, and evaluate responses to therapeutic agents. This knockout model serves as a powerful tool to elucidate the multifaceted interactions occurring within cellular networks.
In scientific research and clinical settings, the availability of CASP8 Gene Knockout Cell Lines opens up diverse pathways for investigation, including drug discovery, functional genomics, and mechanistic studies of disease progression. Compared to traditional wild-type cell lines, these knockout models provide an unprecedented opportunity to dissect the biological ramifications of caspase 8 loss, leading to more targeted therapeutic approaches.
What sets our CASP8 Gene Knockout Cell Lines apart from alternatives on the market is the precision of the gene editing technology employed, ensuring high fidelity and reproducibility in experiments. Additionally, our cell lines are validated for specific marker expression, ensuring that researchers can achieve reliable and meaningful results.
For researchers and clinicians dedicated to advancing the understanding of apoptosis and its clinical ramifications, these cell lines are not only a valuable addition to experimental paradigms but also represent a significant step forward in the quest to unravel complex pathological processes. Our company, specialized in cutting-edge genetic engineering, offers these CASP8 Gene Knockout Cell Lines backed by rigorous validation and extensive technical support, ensuring that users achieve their research objectives with confidence.
Please note that all services are for research use only. Not intended for any clinical use.
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