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CASC3 Knockout Cell Lines

Gene: CASC3

Official Full Name: CASC3 exon junction complex subunitprovided by HGNC

Gene Summary: The product of this gene is a core component of the exon junction complex (EJC), a protein complex that is deposited on spliced mRNAs at exon-exon junctions and functions in nonsense-mediated mRNA decay (NMD). The encoded protein binds RNA and interacts with two other EJC core components. It is predominantly located in the cytoplasm, but shuttles into the nucleus where it localizes to nuclear speckles. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO30324 CASC3 Knockout cell line (HeLa) Human CASC3 1:3~1:6 Negative Online Inquiry
KO30325 CASC3 Knockout cell line (HCT 116) Human CASC3 1:2~1:4 Negative Online Inquiry
KO30326 CASC3 Knockout cell line (HEK293) Human CASC3 1:3~1:6 Negative Online Inquiry
KO30327 CASC3 Knockout cell line (A549) Human CASC3 1:3~1:4 Negative Online Inquiry

Background

CASC3 Gene Knockout Cell Lines are specialized cellular models that have been genetically engineered to disrupt the expression of the CASC3 gene, an essential component involved in the regulation of gene expression and RNA metabolism. These cell lines serve as invaluable tools for researchers seeking to elucidate the role of CASC3 in various biological processes, including signal transduction, cell proliferation, and apoptosis. By utilizing CRISPR-Cas9 technology or other targeted gene-editing techniques, these knockout cell lines allow scientists to analyze the functional consequences of CASC3 deficiency in vitro, providing insights into underlying mechanisms of disease.

The primary function of CASC3 includes its involvement in the assembly of the RNA-induced silencing complex (RISC), crucial for the post-transcriptional regulation of gene expression. By inhibiting CASC3, researchers can study how the disruption of RNA processing and gene silencing pathways can lead to various pathologies, including cancer progression and neurodegenerative diseases. Such insights are pertinent not only for understanding disease mechanisms but also for developing targeted therapeutic strategies.

The scientific importance of CASC3 Gene Knockout Cell Lines extends to applications in both basic research and clinical settings, such as drug discovery and the development of RNA-targeted therapeutics. These cell lines can be utilized to screen for small molecules or RNA therapies that may restore or compensate for CASC3 function, offering novel avenues for treatment.

What sets our CASC3 Gene Knockout Cell Lines apart from alternative models is the precision of the knockout process and the extensive validation these lines have undergone to ensure specificity and relevance. Unlike conventional cell lines that may harbor multiple genetic alterations, our product offers a clean genetic background, providing researchers with consistency and reliability in their experimental results.

Equipped with robust characterization documentation, these cell lines address critical needs within the research community, empowering scientists to deepen their understanding of gene function and regulatory networks. Choosing our CASC3 Gene Knockout Cell Lines means investing in high-quality, cutting-edge biological products supported by our team's expertise in molecular biology and genetics. Our commitment to excellence ensures you have the best resources at your disposal to advance your work in gene expression research and beyond.

Please note that all services are for research use only. Not intended for any clinical use.

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