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CARNMT1 Knockout Cell Lines

Gene: CARNMT1

Official Full Name: carnosine N-methyltransferase 1provided by HGNC

Gene Summary: The protein encoded by this gene is a methyltransferase that converts carnosine to anserine, a dipeptide found abundantly in skeletal muscle. The encoded protein can methylate other dipeptides as well. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO26330 CARNMT1 Knockout cell line (HeLa) Human CARNMT1 1:3~1:6 Negative Online Inquiry
KO26331 CARNMT1 Knockout cell line (HCT 116) Human CARNMT1 1:2~1:4 Negative Online Inquiry
KO26332 CARNMT1 Knockout cell line (HEK293) Human CARNMT1 1:3~1:6 Negative Online Inquiry
KO26333 CARNMT1 Knockout cell line (A549) Human CARNMT1 1:3~1:4 Negative Online Inquiry

Background

CARNMT1 Gene Knockout Cell Lines represent a significant advancement in the field of molecular biology, specifically designed for the study of gene function and cellular mechanisms. These cell lines have been engineered to lack the CARNMT1 gene, which is known to play crucial roles in RNA processing and mitochondrial function. By missing this gene, researchers can investigate the subsequent cellular phenotypes, alterations in metabolic pathways, and impacts on gene expression, providing deeper insights into mitochondrial biology and diseases.

The fundamental mechanism of CARNMT1 involves modulating the post-transcriptional modifications necessary for the maturation of certain mitochondrial RNA species. By utilizing CARNMT1 knockout cell lines, scientists can precisely observe how the absence of this gene alters mitochondrial function, affecting energy metabolism and cellular homeostasis. This enables a closer examination of the pathophysiological consequences that arise from disruptions in mitochondrial RNA processes.

In terms of scientific importance, these cell lines are invaluable for research into various conditions such as neurodegenerative diseases, metabolic syndromes, and certain types of cancer, where mitochondrial dysfunction is a prevalent feature. Moreover, they serve as robust platforms for drug screening and target validation, allowing researchers to identify potential therapeutic strategies aimed at restoring normal mitochondrial function.

What sets CARNMT1 Gene Knockout Cell Lines apart from alternative models is their specificity and authenticity. These cells are developed using cutting-edge CRISPR/Cas9 technology, ensuring precise and reproducible gene editing. Furthermore, they provide a clear advantage over conventional models due to their ability to mirror the complexities of human disease mechanisms more closely.

Researchers and clinicians seeking to deepen their understanding of mitochondrial energy metabolism will find immense value in these cell lines. They not only facilitate the exploration of novel therapeutic avenues but also enhance the capacity for translational research that could lead to impactful clinical applications.

At [Your Company Name], we pride ourselves on our commitment to cutting-edge biotechnology solutions. With extensive expertise in gene editing and cellular biology, our product offerings, including the CARNMT1 Gene Knockout Cell Lines, are designed to empower researchers in their quest for breakthroughs in health and disease.

Please note that all services are for research use only. Not intended for any clinical use.

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