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CARMIL2 Knockout Cell Lines

Gene: CARMIL2

Official Full Name: capping protein regulator and myosin 1 linker 2provided by HGNC

Gene Summary: This gene encodes a member of the CARMIL (capping protein, Arp2/3, myosin-I linker) family of proteins. The encoded protein interacts with and negatively regulates the heterodimeric capping protein and promotes cell migration. Reduced expression of this gene has been observed in human psoriasis patients. Mutations in this gene cause a human immunodeficiency syndrome characterized by smooth muscle tumors and impaired T-cell function. [provided by RefSeq, May 2017]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO24014 CARMIL2 Knockout cell line (HeLa) Human CARMIL2 1:3~1:6 Negative Online Inquiry
KO24015 CARMIL2 Knockout cell line (HCT 116) Human CARMIL2 1:2~1:4 Negative Online Inquiry
KO24016 CARMIL2 Knockout cell line (HEK293) Human CARMIL2 1:3~1:6 Negative Online Inquiry

Background

CARMIL2 Gene Knockout Cell Lines are specifically engineered cellular models that have undergone targeted disruption of the CARMIL2 gene, which plays a crucial role in cytoskeletal dynamics and immune system regulation. These cell lines serve as invaluable tools for researchers investigating the functional implications of CARMIL2 in cellular processes, including cell adhesion, migration, and signal transduction pathways.

The key mechanism by which CARMIL2 influences cellular behavior is rooted in its function as a regulatory protein that interacts with actin filament stabilization and remodeling machinery. By generating knockout models, researchers can directly assess the phenotypic consequences of ablating CARMIL2 expression, thereby elucidating its contributions to various biological phenomena, such as cellular immune responses and tumor biology. This pragmatic approach not only facilitates the dissection of molecular pathways but also aids in the identification of potential therapeutic targets for diseases characterized by aberrant cell signaling.

Scientifically, the CARMIL2 Gene Knockout Cell Lines are imperative for numerous applications in research and clinical settings, including drug discovery, cancer research, and developmental biology. By providing a platform to perform detailed functional assays and therapeutic testing, these models enhance the ability to draw meaningful correlations between gene activity and disease states.

Compared to traditional models, such as wild-type cell lines or less specific knockout approaches, CARMIL2 Gene Knockout Cell Lines present researchers with a refined tool that offers increased specificity and sensitivity for studying CARMIL2-related activities. Their precise genetic modification allows for clearer interpretation of experimental results, reducing confounders that may arise in alternative systems.

This product represents a significant advancement for researchers and clinicians alike, as it not only streamlines the investigative process but also catalyzes novel discoveries in the intricacies of immune regulation and cell biology. Our company prides itself on its commitment to providing high-quality, innovative research tools that empower the scientific community. With extensive expertise in cell line development and gene editing technologies, we ensure that our CARMIL2 Gene Knockout Cell Lines are rigorously validated, delivering reliable results for critical research initiatives.

Please note that all services are for research use only. Not intended for any clinical use.

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