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CAND2 Knockout Cell Lines

Gene: CAND2

Official Full Name: cullin associated and neddylation dissociated 2 (putative)provided by HGNC

Gene Summary: Predicted to enable TBP-class protein binding activity. Predicted to be involved in SCF complex assembly; positive regulation of DNA-templated transcription; and protein ubiquitination. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO29930 CAND2 Knockout cell line (HEK293) Human CAND2 1:3~1:6 Negative Online Inquiry
KO29931 CAND2 Knockout cell line (A549) Human CAND2 1:3~1:4 Negative Online Inquiry

Background

CAND2 Gene Knockout Cell Lines are genetically engineered cellular models that have undergone precise alterations to disrupt the expression of the CAND2 gene, which encodes a crucial protein involved in various cellular processes, including the regulation of protein degradation and response to stress. These knockout cell lines facilitate the in-depth study of CAND2's role in cellular pathways and its implications in various biological contexts, particularly in cancer biology, neurobiology, and developmental studies.

The primary function of CAND2, which acts as a substrate receptor within the Cullin-RING ligase (CRL) complexes, is disrupted in these cell lines, leading to enhanced understanding of the ubiquitin-proteasome system's regulatory mechanisms. By eliminating CAND2 expression, researchers can observe the resulting cellular phenotypes, identify compensatory mechanisms, and assess alterations in protein turnover, thus elucidating the role of this gene in diseases characterized by protein misfolding and aggregation.

The scientific significance of CAND2 Gene Knockout Cell Lines extends beyond basic research, as they hold value in pre-clinical drug testing and development. Their utilization can help in identifying potential therapeutic targets, understanding drug resistance mechanisms, or assessing the effects of novel compounds on cellular homeostasis in a controlled environment.

What sets our CAND2 Gene Knockout Cell Lines apart from alternatives is the precision of the genetic modification and the comprehensive characterization provided with each line. These features ensure reproducibility and reliability in experimental outcomes, allowing researchers to interpret data with confidence. Furthermore, our rigorous quality control processes guarantee that each cell line is validated for functionality, stability, and genetic consistency.

In summary, CAND2 Gene Knockout Cell Lines represent a valuable resource for researchers and clinicians seeking to explore the molecular underpinnings of diseases linked to protein regulation. By investing in these cell lines, users gain access to a robust tool that fosters innovative research and accelerates discoveries in the biomedical field. Our company prides itself on its expertise in developing genetically modified models and is committed to advancing scientific research through high-quality biological products.

Please note that all services are for research use only. Not intended for any clinical use.

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