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CAMK2D Knockout Cell Lines

Gene: CAMK2D

Official Full Name: calcium/calmodulin dependent protein kinase II deltaprovided by HGNC

Gene Summary: The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a delta chain. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Distinct isoforms of this chain have different expression patterns.[provided by RefSeq, Nov 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO01328 CAMK2D Knockout cell line (HeLa) Human CAMK2D 1:3~1:6 Negative Online Inquiry
KO11823 CAMK2D Knockout cell line (HCT 116) Human CAMK2D 1:2~1:4 Negative Online Inquiry
KO11824 CAMK2D Knockout cell line (HEK293) Human CAMK2D 1:3~1:6 Negative Online Inquiry
KO11825 CAMK2D Knockout cell line (A549) Human CAMK2D 1:3~1:4 Negative Online Inquiry

Background

CAMK2D Gene Knockout Cell Lines are sophisticated biological tools designed for in-depth studies involving calcium/calmodulin-dependent protein kinase II delta (CaMKIIδ), a crucial enzyme involved in various cellular processes including synaptic plasticity, cardiac function, and cellular signaling. These cell lines are genetically engineered to disrupt the CAMK2D gene, enabling researchers to investigate the functional roles of CaMKIIδ in health and disease more effectively.

The primary mechanism behind these knockout cell lines involves the use of CRISPR/Cas9 gene-editing technology, which allows for precise alterations in the genomic DNA. By creating a targeted deletion of the CAMK2D gene, researchers can evaluate the consequences of its absence on cellular pathways and behaviors, such as migration, proliferation, and apoptosis. This precise manipulation permits an unparalleled level of control over experimental conditions, leading to more accurate and reproducible data.

The scientific relevance of CAMK2D Gene Knockout Cell Lines extends across multiple fields, including neurobiology and cardiology. In research settings, these cell lines can be used to model pathological conditions such as cardiac arrhythmias or neurodegenerative diseases, facilitating the exploration of novel therapeutic strategies. In clinical applications, the insights gained from studying these knockout lines can pave the way for the development of targeted treatments, potentially altering the course of diseases linked to dysfunctional CaMKIIδ pathways.

One specific advantage of utilizing CAMK2D Gene Knockout Cell Lines is their ability to provide a clear differentiation from alternative models, such as wild-type or poorly characterized cell lines. The targeted knockout ensures that results are directly attributable to the absence of CaMKIIδ, minimizing the confusion often encountered in studies using less precise models. This specificity enhances the overall quality of research outcomes, making these cell lines a highly valuable option for those in academia and clinical research.

In summary, CAMK2D Gene Knockout Cell Lines offer an innovative and reliable approach for investigating the intricate roles of CaMKIIδ in various biological contexts. By choosing our product, researchers benefit from our commitment to quality and our expertise in developing advanced biological tools tailored to meet the evolving needs of the scientific community.

Please note that all services are for research use only. Not intended for any clinical use.

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