Gene: CAMK2B
Official Full Name: calcium/calmodulin dependent protein kinase II betaprovided by HGNC
Gene Summary: The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a beta chain. It is possible that distinct isoforms of this chain have different cellular localizations and interact differently with calmodulin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO11826 | CAMK2B Knockout cell line (HEK293) | Human | CAMK2B | 1:3~1:6 | Negative | Online Inquiry |
CAMK2B Gene Knockout Cell Lines are highly specialized research tools designed to facilitate the study of the calcium/calmodulin-dependent protein kinase II beta (CAMK2B) gene's role in cellular processes. These cell lines have been genetically modified to disrupt the expression of the CAMK2B gene, allowing researchers to investigate the downstream effects of CAMK2B deletion on signaling pathways, cellular metabolism, and overall cellular function.
The principal functionality of these cell lines revolves around their ability to model conditions that mimic CAMK2B dysfunction, which is implicated in various pathologies, including neurological disorders, cardiac diseases, and cancer. By utilizing these knockout cell lines, scientists can elucidate the mechanistic roles of CAMK2B in cellular signaling cascades, assess phenotypic changes in response to different stimuli, and explore potential therapeutic interventions that may restore normal function.
The scientific importance of CAMK2B Gene Knockout Cell Lines lies in their diverse applications in both basic and translational research. They provide a robust platform for drug discovery, functional genomics, and biological pathway analysis, supporting the development of novel therapeutic strategies targeting CAMK2B-related disorders. Given the pivotal role of CAMK2B in synaptic plasticity and learning and memory, these cell lines are especially valuable in neuroscience research.
What sets these knockout cell lines apart from alternatives is their validated genetic background and reproducibility in experimental outcomes. This reliability enables researchers to draw more accurate conclusions regarding the effects of CAMK2B on various physiological processes. Additionally, the convenience of working with standardized cell lines streamlines experimental design and amplifies replicability.
For researchers and clinicians who are committed to unraveling the complexities of CAMK2B-related mechanisms, these Gene Knockout Cell Lines are invaluable assets. They not only enhance the understanding of cellular signaling dynamics but also pave the way for innovative therapeutic approaches. Our company is committed to providing high-quality biological products backed by extensive expertise and rigorous validation, ensuring that researchers have the reliable tools necessary to advance their work in understanding critical biological processes.
Please note that all services are for research use only. Not intended for any clinical use.
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