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CALU Knockout Cell Lines

Gene: CALU

Official Full Name: calumeninprovided by HGNC

Gene Summary: The product of this gene is a calcium-binding protein localized in the endoplasmic reticulum (ER) and it is involved in such ER functions as protein folding and sorting. This protein belongs to a family of multiple EF-hand proteins (CERC) that include reticulocalbin, ERC-55, and Cab45 and the product of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO38694 CALU Knockout cell line (HeLa) Human CALU 1:3~1:6 Negative Online Inquiry
KO38695 CALU Knockout cell line (HCT 116) Human CALU 1:2~1:4 Negative Online Inquiry
KO38696 CALU Knockout cell line (HEK293) Human CALU 1:3~1:6 Negative Online Inquiry
KO38697 CALU Knockout cell line (A549) Human CALU 1:3~1:4 Negative Online Inquiry

Background

CALU Gene Knockout Cell Lines represent a cutting-edge tool in molecular biology designed to facilitate targeted gene disruption in various cellular systems. These engineered cell lines utilize CRISPR/Cas9 technology to effectively knockout specific genes, enabling researchers to study the loss-of-function effects on cellular phenotypes and biological pathways. By generating precise gene deletions, CALU Gene Knockout Cell Lines provide an invaluable resource for elucidating gene function and understanding the molecular mechanisms underlying various diseases.

The primary function of CALU Gene Knockout Cell Lines lies in their ability to model genetic disorders and facilitate drug discovery. The CRISPR/Cas9 mechanism introduces double-strand breaks at targeted genomic loci, which the cell attempts to repair via non-homologous end joining, often resulting in insertions or deletions that disrupt the target gene's reading frame. This innovative approach allows for streamlined and reproducible gene knockout experiments, accelerating the pace of scientific discovery.

In research and clinical settings, these cell lines are pivotal for investigating gene interactions, signaling pathways, and cellular responses to treatment. They are particularly beneficial in cancer research, neurological disorders, and metabolic diseases, where understanding the function of specific genes can guide therapeutic strategies and biomarker identification.

The advantages of CALU Gene Knockout Cell Lines over traditional knockout methods include their high efficiency, reduced time investment, and the ability to generate stable cell lines with defined genetic modifications. This reliability ensures that researchers obtain consistent results that can be replicated across studies, enhancing the credibility and reproducibility of findings.

For researchers and clinicians, CALU Gene Knockout Cell Lines provide a powerful platform for advancing personalized medicine and targeted therapies. The availability of a comprehensive range of knockout lines allows users to explore multiple genetic contexts, thereby broadening the scope of their investigations.

With expertise in innovative biological products, our company is dedicated to providing high-quality research tools that empower scientists and healthcare professionals to unravel complex biological questions and translate discoveries into impactful clinical applications. Our commitment to quality assurance and continuous improvement ensures that our products meet the highest scientific standards, enabling breakthroughs in research and therapeutic development.

Please note that all services are for research use only. Not intended for any clinical use.

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