Gene: CA11
Official Full Name: carbonic anhydrase 11provided by HGNC
Gene Summary: Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA XI is likely a secreted protein, however, radical changes at active site residues completely conserved in CA isozymes with catalytic activity, make it unlikely that it has carbonic anhydrase activity. It shares properties in common with two other acatalytic CA isoforms, CA VIII and CA X. CA XI is most abundantly expressed in brain, and may play a general role in the central nervous system. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO38719 | CA11 Knockout cell line (HeLa) | Human | CA11 | 1:3~1:6 | Negative | Online Inquiry |
KO38720 | CA11 Knockout cell line (HCT 116) | Human | CA11 | 1:2~1:4 | Negative | Online Inquiry |
KO38721 | CA11 Knockout cell line (HEK293) | Human | CA11 | 1:3~1:6 | Negative | Online Inquiry |
KO38722 | CA11 Knockout cell line (A549) | Human | CA11 | 1:3~1:4 | Negative | Online Inquiry |
CA11 Gene Knockout Cell Lines are genetically engineered cell models designed to facilitate the investigation of the carbonic anhydrase 11 (CA11) gene's functional roles in various biological processes. These cell lines specifically lack the expression of the CA11 gene, allowing researchers to study the gene's involvement in physiological and pathological mechanisms without the interfering effects of wild-type activity.
The key functions of CA11 within the body include its roles in maintaining acid-base balance and facilitating the transport of bicarbonate across cell membranes. By utilizing CA11 knockout cell lines, scientists can explore the resulting phenotypic changes, alterations in cellular metabolism, and implications for disease models related to processes such as oxidative stress, neurodegeneration, and tumorigenesis. The elimination of CA11 expression enables researchers to elucidate the pathways it influences, particularly in contexts such as cancer biology and cardiovascular health.
In research and clinical environments, the CA11 Gene Knockout Cell Lines present significant value as a tool for investigating potential therapeutic targets. Their utility in high-throughput screening assays or as models for drug discovery empowers scientists to identify novel compounds that can modulate CA11-related pathways. This precision application of knockout technology amplifies the ability to conduct studies with fewer confounding variables, ultimately leading to clearer insights into gene function and disease mechanisms.
Moreover, the CA11 Gene Knockout Cell Lines offer distinct advantages over traditional models, including improved reproducibility and specificity, enabling more genuine assessments of gene function. Unlike conventional animal models, these cell lines can be manipulated with ease, providing a controlled environment conducive to both pharmacological and genetic studies.
For researchers and clinicians aiming to enhance their understanding of CA11-related biological processes and to develop novel therapeutic strategies, these cell lines are an invaluable asset. Our commitment to quality and innovation as a leading provider of genetic models ensures that our CA11 Gene Knockout Cell Lines facilitate cutting-edge research, seamlessly bridging the gap between fundamental biological studies and clinical applications.
Please note that all services are for research use only. Not intended for any clinical use.
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