Gene: C1GALT1C1
Official Full Name: C1GALT1 specific chaperone 1provided by HGNC
Gene Summary: This gene encodes a type II transmembrane protein that is similar to the core 1 beta1,3-galactosyltransferase 1, which catalyzes the synthesis of the core-1 structure, also known as Thomsen-Friedenreich antigen, on O-linked glycans. This gene product lacks the galactosyltransferase activity itself, but instead acts as a molecular chaperone required for the folding, stability and full activity of the core 1 beta1,3-galactosyltransferase 1. Mutations in this gene have been associated with Tn syndrome. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Dec 2009]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO01530 | C1GALT1C1 Knockout cell line (HeLa) | Human | C1GALT1C1 | 1:3~1:6 | Negative | Online Inquiry |
KO01531 | C1GALT1C1 Knockout cell line (HCT 116) | Human | C1GALT1C1 | 1:2~1:4 | Negative | Online Inquiry |
KO01532 | C1GALT1C1 Knockout cell line (HEK293) | Human | C1GALT1C1 | 1:3~1:6 | Negative | Online Inquiry |
KO01533 | C1GALT1C1 Knockout cell line (A549) | Human | C1GALT1C1 | 1:3~1:4 | Negative | Online Inquiry |
C1GALT1C1 gene knockout cell lines represent a transformative biological tool designed for the targeted study of the C1GALT1C1 gene, which encodes a key enzyme involved in the biosynthesis of glycoproteins and the modulation of cellular interactions. These cell lines are genetically engineered to contain a specific knockout of the C1GALT1C1 gene, facilitating a deeper understanding of its biological functions and its role in various pathological conditions.
The primary function of these cell lines is to enable scientists to investigate the consequences of C1GALT1C1 gene disruption on cellular behaviors, such as growth, differentiation, and response to external stimuli. By employing techniques such as CRISPR-Cas9 gene editing, these cell lines provide a powerful platform for dissecting the mechanistic pathways influenced by the absence of this gene, revealing insights into its implications in diseases like cancer and autoimmune disorders.
This product bears significant scientific importance as it serves research efforts aimed at uncovering the intricate roles of glycosylation in health and disease. In clinical research settings, these knockout models offer enhanced predictivity for drug testing and validation, streamlining the path towards therapeutic developments targeting glycoprotein modulation.
What sets the C1GALT1C1 gene knockout cell lines apart from traditional models is their specificity and precision in gene editing, coupled with extensive validation to ensure reproducibility and reliability of results. Unlike alternative products, these cell lines facilitate an efficient transition from basic research to translational applications, with clear benefits in experimental design and outcome interpretation.
Researchers and clinicians will find exceptional value in these cell lines as they provide comprehensive insights that can inform innovations in targeted therapies and diagnostics. Our commitment to advancing biological research is showcased through our rigorous quality control processes and our dedicated scientific support, ensuring that users can fully leverage the capabilities of these unique cell lines in their research endeavors.
Please note that all services are for research use only. Not intended for any clinical use.
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