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BTN3A1 Knockout Cell Lines

Gene: BTN3A1

Official Full Name: butyrophilin subfamily 3 member A1provided by HGNC

Gene Summary: The butyrophilin (BTN) genes are a group of major histocompatibility complex (MHC)-associated genes that encode type I membrane proteins with 2 extracellular immunoglobulin (Ig) domains and an intracellular B30.2 (PRYSPRY) domain. Three subfamilies of human BTN genes are located in the MHC class I region: the single-copy BTN1A1 gene (MIM 601610) and the BTN2 (e.g., BTN2A1; MIM 613590) and BTN3 (e.g., BNT3A1) genes, which have undergone tandem duplication, resulting in 3 copies of each (summary by Smith et al., 2010 [PubMed 20208008]).[supplied by OMIM, Nov 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO31193 BTN3A1 Knockout cell line (HeLa) Human BTN3A1 1:3~1:6 Negative Online Inquiry
KO31194 BTN3A1 Knockout cell line (HCT 116) Human BTN3A1 1:2~1:4 Negative Online Inquiry
KO31195 BTN3A1 Knockout cell line (HEK293) Human BTN3A1 1:3~1:6 Negative Online Inquiry
KO31196 BTN3A1 Knockout cell line (A549) Human BTN3A1 1:3~1:4 Negative Online Inquiry

Background

BTN3A1 Gene Knockout Cell Lines are specialized cellular models engineered to lack the BTN3A1 gene, a crucial component in immune cell regulation and T cell activation. These knockout cell lines serve as an essential tool for researchers studying the mechanisms of immune evasion in cancer, infectious diseases, and the underlying biology of T cell responses.

The primary function of BTN3A1 lies in its ability to present antigens and modulate immune responses. By knocking out the BTN3A1 gene, these cell lines enable the exploration of alternative immune pathways and the assessment of T cell interactions in the absence of this regulator. Researchers can utilize these models to delve into the roles of BTN3A1 in various immunological contexts, particularly how its absence affects tumor immunity and pathogen recognition.

The scientific importance of BTN3A1 Gene Knockout Cell Lines is evident in their application across both research and clinical settings. Researchers investigating cancer immunotherapy are particularly interested in these models, as they provide insights into how tumor cells may manipulate immune recognition. In clinical research, findings derived from these models can contribute to developing novel therapeutic approaches that enhance immune responses against tumors or infections.

One of the unique selling points of BTN3A1 Gene Knockout Cell Lines is their specificity and reliability for studying BTN3A1's role in T cell biology without the interference of compensatory mechanisms that could arise from partial knockdowns. These cell lines offer a more accurate representation of the gene’s loss, allowing for clearer interpretation of experimental outcomes.

For researchers and clinicians alike, the value of BTN3A1 Gene Knockout Cell Lines cannot be overstated. They facilitate groundbreaking research that can lead to innovative treatments and improved understanding of immune system dynamics. Utilizing these cell lines empowers scientists to unlock new pathways in immunology and cancer biology.

At our company, we pride ourselves on delivering high-quality, rigorously validated biological products that support cutting-edge research efforts. Our expertise in genetic engineering and commitment to advancing scientific knowledge ensure that our BTN3A1 Gene Knockout Cell Lines are a valuable addition to any researcher’s toolkit.

Please note that all services are for research use only. Not intended for any clinical use.

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