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BST1 Knockout Cell Lines

Gene: BST1

Official Full Name: bone marrow stromal cell antigen 1provided by HGNC

Gene Summary: Bone marrow stromal cell antigen-1 is a stromal cell line-derived glycosylphosphatidylinositol-anchored molecule that facilitates pre-B-cell growth. The deduced amino acid sequence exhibits 33% similarity with CD38. BST1 expression is enhanced in bone marrow stromal cell lines derived from patients with rheumatoid arthritis. The polyclonal B-cell abnormalities in rheumatoid arthritis may be, at least in part, attributed to BST1 overexpression in the stromal cell population. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO38775 BST1 Knockout cell line (HEK293) Human BST1 1:3~1:6 Negative Online Inquiry
KO38776 BST1 Knockout cell line (A549) Human BST1 1:3~1:4 Negative Online Inquiry

Background

BST1 Gene Knockout Cell Lines represent a significant advancement in cellular research and therapeutic development. These cell lines are genetically engineered to specifically knock out the BST1 gene, which encodes the bone marrow stromal antigen 1 protein. This protein plays a crucial role in immune response modulation and cellular signaling pathways. By eliminating BST1 expression, these cell lines provide a unique tool for studying the functional implications of this gene in various biological processes.

The primary function of the BST1 Gene Knockout Cell Lines is to facilitate the investigation of immune cell activation, signaling, and interactions within the tumor microenvironment or in response to infectious agents. Through the absence of BST1, researchers can observe changes in cellular behaviors such as proliferation, differentiation, and apoptosis, providing deeper insights into the pathophysiology of diseases like cancer and autoimmune disorders. The underlying mechanism involves alterations in calcium signaling and the modulation of the immune response, which are critical for understanding disease mechanisms and developing targeted therapies.

The scientific importance of these cell lines extends to both research and clinical applications, as they serve as models for evaluating drug responses, assessing immune-related therapies, and dissecting cellular pathways involved in disease progression. By providing a controlled environment to explore the effects of BST1 gene deletion, these cell lines enhance the predictability and reliability of experimental outcomes.

What sets the BST1 Gene Knockout Cell Lines apart from alternative models is their specificity and precision. Conventional models often involve broader genetic modifications that can lead to confounding effects, while our knockout lines allow for a targeted approach, reducing background noise in experimental data. This precision not only aids in elucidating specific biological questions but also enhances reproducibility—an essential factor in advancing research findings.

For researchers and clinicians, investing in BST1 Gene Knockout Cell Lines means gaining access to a cutting-edge resource that can propel their studies forward. The ability to manipulate a specific pathway relevant to immune responses empowers researchers to make more informed decisions in their experimental designs and ultimately, in developing innovative treatment strategies.

Our company is committed to advancing scientific research through high-quality, reliable biological products. With extensive expertise in genetic engineering and cell line development, we strive to provide researchers with the most effective tools to unlock new discoveries and drive therapeutic innovations.

Please note that all services are for research use only. Not intended for any clinical use.

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