Gene: BRWD1
Official Full Name: bromodomain and WD repeat domain containing 1provided by HGNC
Gene Summary: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD) residues which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 2 bromodomains and multiple WD repeats. This gene is located within the Down syndrome region-2 on chromosome 21. Alternative splicing of this gene generates multiple transcript variants encoding distinct isoforms. In mouse, this gene encodes a nuclear protein that has a polyglutamine-containing region that functions as a transcriptional activation domain which may regulate chromatin remodelling and associates with a component of the SWI/SNF chromatin remodelling complex.[provided by RefSeq, Jun 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO01608 | BRWD1 Knockout cell line (HeLa) | Human | BRWD1 | 1:3~1:6 | Negative | Online Inquiry |
KO01609 | BRWD1 Knockout cell line (HCT 116) | Human | BRWD1 | 1:2~1:4 | Negative | Online Inquiry |
KO01610 | BRWD1 Knockout cell line (HEK293) | Human | BRWD1 | 1:3~1:6 | Negative | Online Inquiry |
KO01611 | BRWD1 Knockout cell line (A549) | Human | BRWD1 | 1:3~1:4 | Negative | Online Inquiry |
BRWD1 Gene Knockout Cell Lines are genetically engineered cell models designed to specifically lack the BRWD1 gene, critical for various cellular processes, including chromatin remodeling, transcriptional regulation, and cellular proliferation. These knockout cell lines serve as powerful tools for researchers aiming to investigate the functional roles of BRWD1 in various biological contexts, such as cancer development, cellular differentiation, and response to therapy.
The key mechanism of action of BRWD1 knockout cell lines involves the complete disruption of BRWD1 gene expression. This leads to an altered cellular phenotype, providing insights into the gene's impact on gene expression profiles, signaling pathways, and cellular metabolism. By comparing these knockout cells to wild-type counterparts, scientists can unravel the downstream effects of BRWD1 deficiency, facilitating a deeper understanding of its role in health and disease.
The scientific importance of BRWD1 Gene Knockout Cell Lines extends to diverse applications in both basic and translational research settings. Researchers studying epigenetic modifications, cancer biology, and regenerative medicine can leverage these cell lines to elucidate the underlying mechanisms of related pathologies and develop targeted therapies. Furthermore, these cell lines can aid in drug discovery efforts, allowing for a more refined assessment of therapeutic agents’ efficacy and safety in BRWD1-deficient contexts.
One of the distinct advantages of using our BRWD1 Gene Knockout Cell Lines is their high specificity and reliability, backed by rigorous validation processes. Unlike traditional methods that may rely on pharmacological inhibition, these knockout lines offer a permanent and stable model for assessing gene function. Moreover, our product comes with extensive user support, technical documentation, and optimized culture conditions, which sets us apart from competitors in the market.
The value proposition for researchers and clinicians lies in the ability to conduct more precise experiments and generate reproducible results with these specialized cell lines. By understanding the consequences of BRWD1 gene loss, users can potentially open new avenues for therapeutic intervention in diseases where BRWD1 plays a pivotal role.
Our company specializes in providing high-quality biological research tools designed to advance scientific discovery. With a commitment to excellence and innovation, we ensure that our BRWD1 Gene Knockout Cell Lines meet the stringent needs of researchers and contribute to the advancement of genetic research and therapeutic development.
Please note that all services are for research use only. Not intended for any clinical use.
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