Gene: BRSK2
Official Full Name: BR serine/threonine kinase 2provided by HGNC
Gene Summary: Enables several functions, including ATP binding activity; ATPase binding activity; and magnesium ion binding activity. Involved in several processes, including G2/M transition of mitotic cell cycle; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; and regulation of insulin secretion involved in cellular response to glucose stimulus. Located in centrosome and endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO05654 | BRSK2 Knockout cell line (HCT 116) | Human | BRSK2 | 1:2~1:4 | Negative | Online Inquiry |
KO05655 | BRSK2 Knockout cell line (HEK293) | Human | BRSK2 | 1:3~1:6 | Negative | Online Inquiry |
KO05656 | BRSK2 Knockout cell line (A549) | Human | BRSK2 | 1:3~1:4 | Negative | Online Inquiry |
BRSK2 Gene Knockout Cell Lines are sophisticated biological tools designed to facilitate the exploration of the BRSK2 gene's function, a gene implicated in the regulation of neuronal differentiation and synaptic function. These cell lines have been engineered using CRISPR-Cas9 technology to specifically disrupt the BRSK2 gene, allowing researchers to create a cellular model that mimics the loss-of-function phenotype of BRSK2 in vitro.
The primary function of BRSK2 Gene Knockout Cell Lines is to enable researchers to investigate the roles and mechanisms of BRSK2 in various biological processes, including neurogenesis, metabolism, and cell signaling pathways. This product offers a unique opportunity to study BRSK2’s interactions within signaling networks, elucidating its contributions to pathologies such as neurodegenerative diseases, where dysregulation of neuronal function is critical.
Scientifically, these knockout cell lines serve as invaluable tools in both basic and applied research settings. They can be employed in functional assays, drug screening, and genetics, providing insights that are essential for therapeutic development targeting neurological disorders linked to BRSK2. Additionally, the ability to observe the specific phenotypic changes in BRSK2-deficient cells allows researchers to correlate gene expression with biological outcomes in a controlled environment.
What sets BRSK2 Gene Knockout Cell Lines apart from alternative models is their precision in mimicking the genetic alterations found in human diseases, along with their customizable features. Unlike traditional models, which may not fully replicate human physiology, these cell lines provide a more accurate depiction of BRSK2 dynamics, thus enhancing the reliability of experimental results.
For researchers and clinicians engaged in neurobiology, genetics, or pharmacology, the value of utilizing BRSK2 Gene Knockout Cell Lines lies in their ability to elucidate complex biological questions and accelerate the discovery of novel therapeutic strategies. These innovative cell lines provide an indispensable resource for advancing our understanding of BRSK2’s role in health and disease.
Our company prides itself on its expertise in developing high-quality biological tools that empower scientific discovery. With a commitment to supporting research excellence, we offer not only BRSK2 Gene Knockout Cell Lines but a comprehensive portfolio of tailored solutions for researchers in pursuit of groundbreaking knowledge.
Please note that all services are for research use only. Not intended for any clinical use.
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