Gene: BRK1
Official Full Name: BRICK1 subunit of SCAR/WAVE actin nucleating complexprovided by HGNC
Gene Summary: Enables identical protein binding activity. Contributes to small GTPase binding activity. Involved in Rac protein signal transduction and positive regulation of cellular component organization. Located in extracellular exosome. Part of SCAR complex. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO06786 | BRK1 Knockout cell line (HeLa) | Human | BRK1 | 1:3~1:6 | Negative | Online Inquiry |
KO06787 | BRK1 Knockout cell line (HCT 116) | Human | BRK1 | 1:2~1:4 | Negative | Online Inquiry |
KO06788 | BRK1 Knockout cell line (HEK293) | Human | BRK1 | 1:3~1:6 | Negative | Online Inquiry |
KO06789 | BRK1 Knockout cell line (A549) | Human | BRK1 | 1:3~1:4 | Negative | Online Inquiry |
BRK1 Gene Knockout Cell Lines are genetically engineered cellular models specifically designed to lack the expression of the BRK1 gene, a component implicated in various biological processes, including cell signaling and differentiation. By creating these knockout models, researchers can investigate the functional roles of BRK1 in cellular responses, disease mechanisms, and therapeutic targets. The process of gene knockout typically involves CRISPR-Cas9 technology or other conventional genetic manipulation techniques that ensure the precise elimination of specific genes, allowing for downstream analysis without interference from BRK1.
The primary function of such cell lines is to serve as experimental tools that facilitate the study of gene function and its implications in health and disease. By using BRK1 knockout cell lines, researchers can elucidate the pathway roles of BRK1 in cancer progression, immune response, and stem cell biology, making them invaluable for both basic research and translational studies. The mechanistic insights gained can inform the development of novel therapeutic approaches targeting BRK1-related pathways.
The scientific importance of BRK1 Gene Knockout Cell Lines lies in their potential applications across various domains. In cancer research, these models allow for the investigation of tumor biology and the identification of novel biomarkers. Clinically, they may pave the way for personalized medicine strategies by revealing how the absence of BRK1 influences drug sensitivity or resistance.
What sets BRK1 Gene Knockout Cell Lines apart from traditional cell lines or other knockout models is their highly specific and reproducible nature, coupled with rigorous validation processes. Unlike standard cell lines that may exhibit heterogeneous genetic backgrounds, our engineered models provide a consistent platform for experiments, ensuring that any observations are directly attributable to the absence of BRK1.
For researchers and clinicians looking to delve into the genetic underpinnings of disease or potential therapeutic strategies, our BRK1 Gene Knockout Cell Lines offer unparalleled value. These models enhance the reliability of research findings and promote more informed decisions in clinical contexts, ultimately contributing to advancements in biomedical science.
Backed by years of expertise in genetic engineering and cell biology, our company is committed to providing high-quality biological products that meet the growing demands of scientific research and clinical application.
Please note that all services are for research use only. Not intended for any clinical use.
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