Gene: BPNT1
Official Full Name: 3'(2'), 5'-bisphosphate nucleotidase 1provided by HGNC
Gene Summary: BPNT1, also called bisphosphate 3-prime-nucleotidase, or BPntase, is a member of a magnesium-dependent phosphomonoesterase family. Lithium, a major drug used to treat manic depression, acts as an uncompetitive inhibitor of BPntase. The predicted human protein is 92% identical to mouse BPntase. BPntase's physiologic role in nucleotide metabolism may be regulated by inositol signaling pathways. The inhibition of human BPntase may account for lithium-induced nephrotoxicity. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO31939 | BPNT1 Knockout cell line (HeLa) | Human | BPNT1 | 1:3~1:6 | Negative | Online Inquiry |
KO31940 | BPNT1 Knockout cell line (HCT 116) | Human | BPNT1 | 1:2~1:4 | Negative | Online Inquiry |
KO31941 | BPNT1 Knockout cell line (HEK293) | Human | BPNT1 | 1:3~1:6 | Negative | Online Inquiry |
KO31942 | BPNT1 Knockout cell line (A549) | Human | BPNT1 | 1:3~1:4 | Negative | Online Inquiry |
BPNT1 Gene Knockout Cell Lines are expertly engineered cellular models that feature the deletion of the BPNT1 gene, which encodes for the enzyme bisphosphate nucleotidase 1. This product serves as a vital tool for researchers seeking to explore the physiological and pathological roles of BPNT1 in various biological processes, particularly in nucleotide metabolism and related signaling pathways. By facilitating the study of gene function and potential gene therapy strategies, these knockout cell lines provide invaluable insights into cellular mechanisms.
The key function of BPNT1 Gene Knockout Cell Lines lies in their ability to highlight the consequences of BPNT1 deficiency. The lack of this enzyme affects the regulation of intracellular levels of bisphosphate nucleotides, which can have downstream effects on metabolic pathways, DNA repair, and stress responses. Researchers can utilize these cell lines to investigate critical biological phenomena such as cell proliferation, apoptosis, and metabolic shifts, all of which are often compromised in disease states.
The scientific importance of these cell lines extends to multiple research domains, including cancer biology, metabolic disorders, and genetic studies. In clinical settings, understanding the mechanisms underlying BPNT1 function can pave the way for novel therapeutic targets, particularly in diseases where nucleotide metabolism is disrupted. Additionally, BPNT1 knockout models facilitate drug efficacy screening and toxicity assessments, enhancing the translational potential of therapeutic strategies.
Compared to existing cell models, BPNT1 Gene Knockout Cell Lines stand out due to their specificity and precision in targeting a single gene without compromising overall cellular integrity. This selectivity allows researchers to generate reproducible and reliable results, making these cell lines superior to traditional knockdown approaches, which may yield off-target effects and inconsistent expression levels.
By providing an innovative, validated resource for genetic and biochemical studies, BPNT1 Gene Knockout Cell Lines represent a valuable asset for researchers and clinicians alike. Their precision in mimicking disease states enables more accurate experimental designs and can accelerate the discovery of novel therapeutics.
Our company prides itself on specializing in the development of high-quality biological research tools that advance scientific discovery and innovation. With a commitment to excellence and integrity, we ensure that our researchers have access to reliable and advanced products, thereby facilitating groundbreaking research across diverse fields.
Please note that all services are for research use only. Not intended for any clinical use.
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