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BNIP3L Knockout Cell Lines

Gene: BNIP3L

Official Full Name: BCL2 interacting protein 3 likeprovided by HGNC

Gene Summary: This gene encodes a protein that belongs to the pro-apoptotic subfamily within the Bcl-2 family of proteins. The encoded protein binds to Bcl-2 and possesses the BH3 domain. The protein directly targets mitochondria and causes apoptotic changes, including loss of membrane potential and the release of cytochrome c. [provided by RefSeq, Feb 2015]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO00745 BNIP3L Knockout cell line (HeLa) Human BNIP3L 1:3~1:6 Negative Online Inquiry
KO19394 BNIP3L Knockout cell line (HCT 116) Human BNIP3L 1:2~1:4 Negative Online Inquiry
KO19395 BNIP3L Knockout cell line (HEK293) Human BNIP3L 1:3~1:6 Negative Online Inquiry
KO19396 BNIP3L Knockout cell line (A549) Human BNIP3L 1:3~1:4 Negative Online Inquiry

Background

BNIP3L Gene Knockout Cell Lines are meticulously engineered cellular systems that have been created to study the biological functions and molecular mechanisms of the BNIP3L gene, which is pivotal in the regulation of autophagy and cellular metabolism. By specifically knocking out this gene, researchers can explore the downstream effects on cellular processes, informing our understanding of pathologies associated with abnormal autophagy, including cancer, neurodegeneration, and cardiovascular diseases.

These cell lines function by utilizing CRISPR-Cas9 genome editing technology to create precise deletions or disruptions of the BNIP3L gene. This knockout allows scientists to investigate loss-of-function phenotypes and analyze the role of BNIP3L in autophagic pathways, mitochondrial clearance, and the cellular response to stress. Such investigations are essential for elucidating the gene's contribution to disease mechanisms and for identifying potential therapeutic targets.

The scientific importance of BNIP3L Gene Knockout Cell Lines is evident in both basic research and clinical applications. In the realm of research, these cell lines serve as invaluable tools for screening potential drugs or interventions that could modulate autophagy-related processes. Clinically, they hold promise in understanding patient-specific responses to therapies in conditions characterized by dysregulated autophagy.

Advantages of this product include its high specificity, reproducibility, and robust performance in various experimental conditions. Unlike alternative methods that may yield off-target effects or incomplete gene knockouts, our precisely engineered cell lines offer reliable insights into BNIP3L functions. Additionally, they are compatible with standard cell culture practices, making them easy to implement in diverse laboratory settings.

For researchers and clinicians seeking to understand the complexities of autophagic processes or to develop targeted therapies, BNIP3L Gene Knockout Cell Lines represent a powerful resource. Furthermore, our company is dedicated to offering high-quality biological products, backed by expert knowledge in genetic engineering and cell biology, ensuring that our customers have access to innovative tools that enhance their research and clinical capabilities.

Please note that all services are for research use only. Not intended for any clinical use.

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