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BMP7 Knockout Cell Lines

Gene: BMP7

Official Full Name: bone morphogenetic protein 7provided by HGNC

Gene Summary: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone, kidney and brown adipose tissue development. Additionally, this protein induces ectopic bone formation and may promote fracture healing in human patients. [provided by RefSeq, Jul 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO11579 BMP7 Knockout cell line (HCT 116) Human BMP7 1:2~1:4 Negative Online Inquiry
KO11580 BMP7 Knockout cell line (HEK293) Human BMP7 1:3~1:6 Negative Online Inquiry

Background

BMP7 Gene Knockout Cell Lines are specifically engineered cellular models designed to study the function of the Bone Morphogenetic Protein 7 (BMP7) gene, a pivotal component involved in various biological processes, including bone development, tissue regeneration, and cellular signaling pathways. These cell lines have been generated through CRISPR/Cas9 technology, allowing for precise elimination of the BMP7 gene, which enables researchers to observe the resultant phenotypic changes and underlying molecular mechanisms that contribute to bone and organ development.

The primary functions of BMP7 include promoting osteogenesis and regulating the differentiation of mesenchymal stem cells. By creating BMP7 knockout cell lines, researchers can investigate the gene's role in these processes and elucidate the signaling pathways that involve BMP7, such as the Smad pathway. This understanding has significant implications in various areas of research, particularly in developmental biology, regenerative medicine, and studies related to degenerative diseases. The insights gained can inform the development of therapeutic strategies for conditions like osteoporosis, fractures, and chronic wounds.

Compared to traditional cell lines that retain the BMP7 gene, our BMP7 Gene Knockout Cell Lines offer a unique advantage by enabling direct assessment of BMP7's impact without confounding by its expression. This specificity enhances data clarity and reduces variability, making it easier for users to derive meaningful conclusions in their studies. Furthermore, the use of these knockout models can streamline the development of BMP-related therapies by identifying potential drug targets and enabling toxicology studies in a more controlled environment.

For researchers, clinicians, and biotech companies focused on advancing knowledge in osteogenesis and regenerative applications, the BMP7 Gene Knockout Cell Lines present a valuable tool. Their easy handling and compatibility with common laboratory protocols enhance their practicality in various experimental setups. At [Your Company Name], we specialize in providing high-quality biological products that empower scientists to innovate and explore novel therapeutic pathways.

Please note that all services are for research use only. Not intended for any clinical use.

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