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BMP2K Knockout Cell Lines

Gene: BMP2K

Official Full Name: BMP2 inducible kinaseprovided by HGNC

Gene Summary: This gene is the human homolog of mouse BMP-2-inducible kinase. Bone morphogenic proteins (BMPs) play a key role in skeletal development and patterning. Expression of the mouse gene is increased during BMP-2 induced differentiation and the gene product is a putative serine/threonine protein kinase containing a nuclear localization signal. Therefore, the protein encoded by this human homolog is thought to be a protein kinase with a putative regulatory role in attenuating the program of osteoblast differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO19406 BMP2K Knockout cell line (HeLa) Human BMP2K 1:3~1:6 Negative Online Inquiry
KO19407 BMP2K Knockout cell line (HCT 116) Human BMP2K 1:2~1:4 Negative Online Inquiry
KO19408 BMP2K Knockout cell line (HEK293) Human BMP2K 1:3~1:6 Negative Online Inquiry
KO19409 BMP2K Knockout cell line (A549) Human BMP2K 1:3~1:4 Negative Online Inquiry

Background

BMP2K Gene Knockout Cell Lines represent a highly specialized biological tool designed to facilitate the study of bone morphogenetic protein signaling pathways and their implications in various physiological and pathological conditions. These cell lines are genetically modified to lack the expression of the BMP2K gene, which encodes for a protein known to play a pivotal role in regulating bone and cartilage development through modulating BMP signaling. By utilizing these knockout cell lines, researchers can directly investigate the effects of BMP2K loss on cell behavior, differentiation, and the underlying mechanisms that drive these processes.

The primary function of these cell lines lies in their ability to serve as a model for various experiments aimed at elucidating the pathogenic role of aberrant BMP signaling in diseases such as osteoarthritis, osteoporosis, and cancer. By comparing the BMP2K knockout cells to wild-type counterparts, scientists can uncover critical insights into cellular responses, gene expression patterns, and the functional consequences of disrupted signaling pathways, significantly enhancing the understanding of bone biology.

From a scientific standpoint, BMP2K Gene Knockout Cell Lines are invaluable in both research and clinical contexts. They facilitate hypothesis-driven studies on the development of novel therapeutics aimed at modulating BMP signaling. Furthermore, they are crucial for the development of regenerative medicine strategies, including bone and cartilage repair.

One of the significant advantages of our BMP2K Gene Knockout Cell Lines lies in their high specificity and reliability compared to traditional methods, such as pharmacological inhibitors or siRNA approaches. These cells provide a stable and consistent model that accurately reflects the loss of BMP2K, thus eliminating potential off-target effects associated with alternative strategies.

For researchers and clinicians alike, these knockout cell lines represent a powerful resource in the quest to explore complex biological pathways, identify novel therapeutic targets, and develop innovative treatments. Our company prides itself on its expertise in producing top-tier genetic models, ensuring that our products uphold the highest standards of scientific integrity and utility, thus empowering the global research community to drive forward biological discovery.

Please note that all services are for research use only. Not intended for any clinical use.

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