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BLOC1S5 Knockout Cell Lines

Gene: BLOC1S5

Official Full Name: biogenesis of lysosomal organelles complex 1 subunit 5provided by HGNC

Gene Summary: This gene encodes a component of BLOC-1 (biogenesis of lysosome-related organelles complex 1). Components of this complex are involved in the biogenesis of organelles such as melanosomes and platelet-dense granules. A mouse model for Hermansky-Pudlak Syndrome is mutated in the murine version of this gene. Alternative splicing results in multiple transcript variants. Read-through transcription exists between this gene and the upstream EEF1E1 (eukaryotic translation elongation factor 1 epsilon 1) gene, as well as with the downstream TXNDC5 (thioredoxin domain containing 5) gene. [provided by RefSeq, Dec 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO19426 BLOC1S5 Knockout cell line (HeLa) Human BLOC1S5 1:3~1:6 Negative Online Inquiry
KO19427 BLOC1S5 Knockout cell line (HCT 116) Human BLOC1S5 1:2~1:4 Negative Online Inquiry
KO19428 BLOC1S5 Knockout cell line (HEK293) Human BLOC1S5 1:3~1:6 Negative Online Inquiry
KO19429 BLOC1S5 Knockout cell line (A549) Human BLOC1S5 1:3~1:4 Negative Online Inquiry

Background

BLOC1S5 Gene Knockout Cell Lines are genetically engineered cell lines specifically altered to disrupt the expression of the BLOC1S5 gene, which is critical for understanding its functions in cellular processes and disease models. These knockout cell lines serve as valuable tools for researchers aiming to elucidate the role of BLOC1S5 in various biological pathways, particularly those linked to pigmentation and neural function.

At the cellular level, the BLOC1S5 gene is part of the biogenesis of lysosome-related organelles complex (BLOC), which plays a pivotal role in the sorting and transport of proteins essential for organelle function. By utilizing these knockout cell lines, researchers can investigate the downstream effects of BLOC1S5 disruption, allowing for a clearer understanding of its implications in conditions such as Hermansky-Pudlak syndrome and other neurodegenerative diseases. The mechanisms observed in these models can provide insights into cellular dysregulation and potential therapeutic targets.

The scientific importance of BLOC1S5 Gene Knockout Cell Lines extends to both basic research and clinical applications. In research settings, they facilitate the study of gene function and protein interactions, enabling discovery-driven investigations that can lead to novel hypotheses and therapeutic avenues. Clinically, the insights gained from these models can inform the development of targeted treatments for genetic disorders associated with lysosomal dysfunction.

What sets BLOC1S5 Gene Knockout Cell Lines apart from alternative models is the precision of gene editing techniques used to generate these lines, ensuring a reliable and reproducible system for experimental replicability. Additionally, these cell lines arise from well-characterized parental cell types, allowing users to better correlate findings with physiological relevance.

Researchers and clinicians alike can leverage the unique capabilities of BLOC1S5 Gene Knockout Cell Lines to propel their understanding of complex biological systems and disease mechanisms. As a leader in the production of high-quality biological research tools, our company is committed to providing advanced genetic models that empower groundbreaking scientific discovery and contribute to the advancement of health research.

Please note that all services are for research use only. Not intended for any clinical use.

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