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BLOC1S3 Knockout Cell Lines

Gene: BLOC1S3

Official Full Name: biogenesis of lysosomal organelles complex 1 subunit 3provided by HGNC

Gene Summary: This gene encodes a protein that is a component of the BLOC1 multi-subunit protein complex. This complex is necessary for the biogenesis of specialized organelles of the endosomal-lysosomal system, including platelet dense granules and melanosomes. Mutations in this gene cause Hermansky-Pudlak syndrome 8, a disease characterized by lysosomal storage defects, bleeding due to platelet storage pool deficiency, and oculocutaneous albinism. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO19434 BLOC1S3 Knockout cell line (HeLa) Human BLOC1S3 1:3~1:6 Negative Online Inquiry
KO19435 BLOC1S3 Knockout cell line (HCT 116) Human BLOC1S3 1:2~1:4 Negative Online Inquiry
KO19436 BLOC1S3 Knockout cell line (HEK293) Human BLOC1S3 1:3~1:6 Negative Online Inquiry
KO19437 BLOC1S3 Knockout cell line (A549) Human BLOC1S3 1:3~1:4 Negative Online Inquiry

Background

BLOC1S3 Gene Knockout Cell Lines represent a cutting-edge tool for genetic research and therapeutic applications, engineered to specifically disrupt the BLOC1S3 gene. BLOC1S3, part of the biogenesis of lysosome-related organelles complex, plays a crucial role in various cellular processes including protein trafficking and lysosomal function. Through targeted gene editing techniques such as CRISPR-Cas9, these cell lines have been created to provide researchers with a reliable platform for exploring the functional consequences of BLOC1S3 gene deficiency, thereby elucidating its role in cellular mechanisms and potential association with diseases.

The key functions of the BLOC1S3 knockout cell lines rely on their ability to model the effects of BLOC1S3 gene silencing in vitro. By enabling a clear understanding of gene expression patterns and cellular phenotypes under conditions where BLOC1S3 is inactive, researchers can examine a range of biological behaviors including autophagy, endocytosis, and the pathophysiology of lysosomal storage disorders. This functionality not only holds promise for basic research but also contributes to translational medicine by providing insights into potential therapeutic approaches for associated diseases.

Scientifically, these knockout cell lines are invaluable in both research and clinical settings, facilitating the study of gene function and drug response in a controlled environment. Compared to existing alternatives, such as RNA interference methods, the knockout approach delivers a more permanent and effective solution, minimizing off-target effects and yielding clearer experimental outcomes. Researchers benefit from enhanced reproducibility and specificity, key factors when conducting high-stakes investigations.

For clinicians and translational researchers, the ability to model human diseases at the cellular level greatly enhances the potential for discovering novel therapeutic strategies and developing targeted interventions. The BLOC1S3 Gene Knockout Cell Lines not only advance understanding in fundamental biology but also propel clinical innovations in gene therapy and regenerative medicine.

At our company, we pride ourselves on cutting-edge biotechnological development and a commitment to scientific excellence, ensuring that our products, such as the BLOC1S3 Gene Knockout Cell Lines, empower researchers and clinicians to achieve their goals with precision and confidence.

Please note that all services are for research use only. Not intended for any clinical use.

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