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BFAR Knockout Cell Lines

Gene: BFAR

Official Full Name: bifunctional apoptosis regulatorprovided by HGNC

Gene Summary: Enables caspase binding activity; protein-macromolecule adaptor activity; and ubiquitin protein ligase activity. Involved in negative regulation of IRE1-mediated unfolded protein response; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein ubiquitination. Acts upstream of or within negative regulation of apoptotic process. Located in endoplasmic reticulum and membrane. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO22723 BFAR Knockout cell line (HeLa) Human BFAR 1:3~1:6 Negative Online Inquiry
KO22724 BFAR Knockout cell line (HCT 116) Human BFAR 1:2~1:4 Negative Online Inquiry
KO22725 BFAR Knockout cell line (HEK293) Human BFAR 1:3~1:6 Negative Online Inquiry
KO22726 BFAR Knockout cell line (A549) Human BFAR 1:3~1:4 Negative Online Inquiry

Background

BFAR Gene Knockout Cell Lines are a cutting-edge tool designed for precise genetic manipulation, specifically targeting the BFAR (Bcl-2 family apoptosis regulator) gene. These cell lines have been engineered using advanced CRISPR/Cas9 technology to create knockout models, enabling researchers to explore the role of the BFAR gene in various cellular processes such as apoptosis, cell proliferation, and tumorigenesis. By eliminating the expression of BFAR, scientists can investigate how this gene contributes to the cellular mechanisms underpinning disease pathology and therapeutic responses, offering crucial insights into cancer biology and treatment strategies.

The key mechanism behind BFAR Gene Knockout Cell Lines relies on the CRISPR/Cas9 system, which introduces a double-strand break at a specific location within the genome. Cell repair attempts ultimately lead to disruptive mutations that result in the loss of gene function, effectively creating a knockout model. This powerful technique allows for rapid and efficient editing of the genome, making it a preferred method in contemporary genetic research.

The scientific importance of these cell lines extends to both academic research and clinical settings, serving as invaluable tools for studying the intricate pathways involved in disease states and drug responses. Researchers can utilize these knockout cell lines for drug screening, biomarker discovery, and elucidating mechanisms of resistance to therapies, all of which can inform the development of targeted treatments.

What sets BFAR Gene Knockout Cell Lines apart from alternative gene editing models is their specificity and ease of use, allowing for straightforward integration into existing research workflows. Unlike other knockout methods that may exhibit off-target effects or variability in gene disruption, the precision of CRISPR technology ensures consistent and reproducible results, giving researchers the confidence to draw meaningful conclusions.

For researchers and clinicians focused on understanding the intricacies of apoptosis and cancer biology, BFAR Gene Knockout Cell Lines offer a valuable resource that enhances research capabilities and accelerates discoveries. By leveraging these advanced models, users can expand their investigations into the multifaceted roles of the BFAR gene in human health and disease.

Our company is committed to providing high-quality biological products and services that empower the scientific community. With a focus on innovation and rigor, we support researchers in their quest for knowledge and breakthroughs in biomedical research.

Please note that all services are for research use only. Not intended for any clinical use.

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