Gene: BEST3
Official Full Name: bestrophin 3provided by HGNC
Gene Summary: BEST3 belongs to the bestrophin family of anion channels, which includes BEST1 (MIM 607854), the gene mutant in vitelliform macular dystrophy (VMD; MIM 153700), and 2 other BEST1-like genes, BEST2 (MIM 607335) and BEST4 (MIM 607336). Bestrophins are transmembrane (TM) proteins that share a homology region containing a high content of aromatic residues, including an invariant arg-phe-pro (RFP) motif. The bestrophin genes share a conserved gene structure, with almost identical sizes of the 8 RFP-TM domain-encoding exons and highly conserved exon-intron boundaries. Each of the 4 bestrophin genes has a unique 3-prime end of variable length (Stohr et al., 2002 [PubMed 12032738]; Tsunenari et al., 2003 [PubMed 12907679]).[supplied by OMIM, Mar 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO03429 | BEST3 Knockout cell line (HeLa) | Human | BEST3 | 1:3~1:6 | Negative | Online Inquiry |
KO03430 | BEST3 Knockout cell line (A549) | Human | BEST3 | 1:3~1:4 | Negative | Online Inquiry |
BEST3 Gene Knockout Cell Lines are a powerful tool in the field of molecular biology, specifically designed to study the roles of the BEST3 gene in various physiological and pathological processes. These cell lines have undergone precise genetic modification through CRISPR/Cas9 technology, resulting in the complete disruption of the BEST3 gene. This knockout allows researchers to investigate the gene's functions, assess its involvement in diseases, and explore therapeutic potential in a controlled environment.
The key function of BEST3 Gene Knockout Cell Lines lies in their ability to provide insights into the mechanisms by which the BEST3 gene influences cellular processes such as ion transport, signaling pathways, and disease progression, particularly in conditions like retinal degeneration and other Best disease-related disorders. By enabling researchers to compare knockout cells with wild-type controls, these cell lines facilitate the identification of specific phenotypic changes and molecular markers associated with BEST3 dysfunction.
The scientific importance of BEST3 Gene Knockout Cell Lines extends to both basic research and translational studies. In academic labs, these models are invaluable for elucidating gene function and interaction networks. In clinical settings, they offer a platform for testing the efficacy of potential therapeutics targeting BEST3-related pathways, thereby accelerating the drug development process.
What sets BEST3 Gene Knockout Cell Lines apart from other genetic models is their high fidelity and reproducibility. Established using state-of-the-art methodologies, these cell lines are rigorously validated, ensuring consistency in experimental results. Additionally, they come with comprehensive support documentation, allowing for seamless integration into existing research workflows.
For researchers and clinicians seeking to deepen their understanding of BEST3 and its implications in human health, these cell lines represent a critical resource. They not only enhance experimental rigor but also pave the way for innovative discoveries that could lead to breakthroughs in disease treatment.
Our company is dedicated to advancing biological research through the development of high-quality, reliable tools like BEST3 Gene Knockout Cell Lines. With a strong foundation in genetic engineering and molecular biology, we pride ourselves on delivering products that are both scientifically robust and user-friendly, empowering researchers to achieve their investigative goals.
Please note that all services are for research use only. Not intended for any clinical use.
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