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BCO1 Knockout Cell Lines

Gene: BCO1

Official Full Name: beta-carotene oxygenase 1provided by HGNC

Gene Summary: Vitamin A metabolism is important for vital processes such as vision, embryonic development, cell differentiation, and membrane and skin protection. The protein encoded by this gene is a key enzyme in beta-carotene metabolism to vitamin A. It catalyzes the oxidative cleavage of beta,beta-carotene into two retinal molecules. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO21933 BCO1 Knockout cell line (A549) Human BCO1 1:3~1:4 Negative Online Inquiry

Background

BCO1 Gene Knockout Cell Lines are invaluable tools designed for the study of biological processes and the functional characterization of the BCO1 gene, which encodes the enzyme beta-carotene-15,15'-dioxygenase. These engineered cell lines have been specifically modified to lack the BCO1 gene, enabling researchers to investigate the metabolic pathways associated with carotenoid cleavage and the subsequent effects on vitamin A biosynthesis. By elucidating the role of BCO1 in various physiological contexts, these cell lines facilitate a deeper understanding of carotenoid metabolism and its implications in health and disease.

The primary function and mechanism of action of BCO1 Gene Knockout Cell Lines lie in their ability to provide insight into the biochemical consequences of the absence of BCO1 activity. This enables studies on how disrupted carotenoid metabolism influences cellular processes, such as differentiation, apoptosis, and oxidative stress responses. Furthermore, researchers can use these cell lines to screen for potential therapeutic agents that may restore or modulate the activity of the BCO1 pathway, opening new avenues for intervention in related metabolic disorders.

The scientific importance of BCO1 Gene Knockout Cell Lines is underscored by their applications in both basic and applied research settings. They serve as a critical resource for investigating the genetic foundations of carotenoid-related diseases, studying the interplay between nutrition and genetics, and developing novel dietary interventions aimed at enhancing health outcomes. Additionally, these cell lines can be utilized to model certain conditions, such as metabolic syndrome and age-related macular degeneration, which are linked to altered vitamin A metabolism.

What sets BCO1 Gene Knockout Cell Lines apart from alternative models is their specificity and reliability. By providing a clear delineation of the BCO1 knockout condition, these cell lines reduce variability and confounding factors that can obscure experimental results. They also allow for the controlled study of BCO1 function without the influence of compensatory mechanisms often present in other models, thus yielding more robust and reproducible data.

For researchers and clinicians alike, BCO1 Gene Knockout Cell Lines represent a crucial asset that enhances the precision of experimental designs and accelerates the translation of laboratory findings into clinical applications. Their ability to unveil the complexities of carotenoid metabolism and its systemic effects illustrates their essential role in advancing our understanding of nutritional biochemistry and its clinical implications.

Our company is committed to providing high-quality biological products, and we leverage our expertise in genetic engineering to deliver reliable tools like the BCO1 Gene Knockout Cell Lines, empowering researchers with the resources they need to uncover new scientific knowledge and drive innovation in health and medicine.

Please note that all services are for research use only. Not intended for any clinical use.

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